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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Notch

Adequacy of energy and macronutrients intake in differently active slovenian adolescents

280 views | Apr 21 2023

The study found that a significant proportion of Slovenian adolescents are not meeting national recommendations for energy and macronutrient intake, and there were differences in energy/macronutrient intake between boys of different physical activity levels, highlighting the need for interventions to encourage healthy eating and physical activity behaviors. [Read the Full Post]

Perinatal Stressors as a Factor in Impairments to Nervous System Development and Functions: Review of In Vivo Models

212 views | Apr 21 2023

This review evaluates different models of perinatal pathology and their relationship with psychoemotional stressors in understanding the impact of stress on the developing brain and behavior. [Read the Full Post]

Targeted inhibition of RBPJ transcription complex alleviates the exhaustion of CD8+ T cells in hepatocellular carcinoma

81 views | Apr 17 2023

This study suggests that targeting the RBPJ transcription complex with a small molecule compound may be a promising strategy for immunotherapy of hepatocellular carcinoma by inhibiting the malignant behaviors of HCC cells and alleviating T cell exhaustion. [Read the Full Post]

Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ

148 views | Apr 17 2023

RBPJ Inhibitor-1 (RIN1) is a new class of small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ, which can be exploited for chemical biology and therapeutic applications, and may lead to more specific and targeted therapies for diseases involving NOTCH signaling. [Read the Full Post]

Towards personalized treatment with clozapine

196 views | Mar 30 2023

This study found that clozapine was more effective when used as a first- or second-line treatment, and identified factors associated with response to clozapine treatment and side effects, which could aid in the development of personalized treatment approaches for individuals with treatment-resistant schizophrenia. [Read the Full Post]

Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture

174 views | Mar 30 2023

The study suggests that targeting the Hedgehog signaling pathway and cancer stem cells using inhibitors like AY9944 and GANT61 can improve the sensitivity of anti-cancer drug treatment in colorectal tumor patient-derived ALI organoids and may be a useful combinational therapeutic strategy against metastatic colorectal cancer. [Read the Full Post]

LY450139 Inhibited Ti-Particle-Induced Bone Dissolution via Suppressing Notch and NF-κB Signaling Pathways

126 views | Feb 27 2023

The study found that LY450139 has the potential to prevent the failure of joint implants by inhibiting the formation of osteoclasts, which break down bone, through the inhibition of the NF-κB and Notch signaling pathways. [Read the Full Post]

Notch signaling-induced cyclin d1 in diabetes ameliorating effects of the isolated polysaccharide from Rosa canina: In vitro and in vivo studies

147 views | Nov 30 2022

Soraya Sajadimajd et al. thought that upregulation of Notch signaling-induced cyclin d1 could be proposed as the underlying diabetes-reducing effects of the isolated polysaccharide derivative. [Read the Full Post]

ATRA works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T-cells

81 views | Oct 10 2022

Estefanía García-Guerrero et al. found that ATRA treatment lead to enhanced BCMA expression on MM cells and consecutively, enhanced reactivity of BCMA-CAR T-cells. [Read the Full Post]

Down-regulated NEDD4L facilitates tumor progression through activating Notch signaling in lung adenocarcinoma

122 views | Aug 25 2022

Liping Lin et al. demonstrated that down-regulated NEDD4L facilitated LUAD progression by activating Notch signaling, and NEDD4L might be a promising target to treat LUAD. [Read the Full Post]