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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

p38 MAPK

Identification of a cancer-associated fibroblast classifier for predicting prognosis and therapeutic response in lung squamous cell carcinoma

51 views | Dec 28 2023

This comprehensive study unveils a robust molecular classifier for high-risk cancer-associated fibroblasts (CAFs)-related lung squamous cell carcinoma (LUSC) patients, suggesting potential therapeutic targets within the PI3K-Akt signaling pathway and identifying promising compounds for more effective personalized treatments. [Read the Full Post]

Exercise attenuates neuronal degeneration in Parkinson's disease rat model by regulating the level of adenosine 2A receptor

275 views | Dec 23 2023

Exercise appears to mitigate Parkinson's disease symptoms in rats by reducing neurodegeneration through a-synuclein aggregation reduction and adenosine 2A receptor modulation, although the co-administration of an adenosine A2A receptor agonist reverses these beneficial effects. [Read the Full Post]

Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier

0 views | Dec 19 2023

In this study, researchers identified the p38 MAPK pathway as a crucial target for mitigating SARS-CoV-2-induced inflammatory responses, demonstrating that selective inhibitors PH-797804 and VX-702, when used individually or in combination with antiviral drugs Remdesivir and Molnupiravir, markedly reduced pro-inflammatory cytokine expression and suppressed viral replication without compromising the interferon-mediated antiviral response in human lung tissues. [Read the Full Post]

Tight junction and kidney stone disease

42 views | Dec 03 2023

The review discusses the involvement of tight junction defects in kidney stone disease, emphasizing the disruption of renal tubular epithelial cell tight junctions by calcium oxalate crystals and genetic factors, and explores potential therapeutic strategies targeting tight junction function. [Read the Full Post]

Regional regulatory harmonisation initiatives: Their potential contribution to the newly established African medicines agency

276 views | Nov 30 2023

The study highlights the foundational role of regional medicines regulatory harmonization programs, such as the African Medicines Regulatory Harmonisation (AMRH) and East African Community Medicines Regulatory Harmonisation (EAC-MRH) initiatives, in supporting the operationalization of the African Medicine Agency (AMA), emphasizing the importance of strong national regulatory authorities and increased ratification of the AMA Treaty for ensuring access to essential medical products and technologies for the African people. [Read the Full Post]

Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of Concern

34 views | Nov 06 2023

The combination of pamapimod and pioglitazone has shown potent and synergistic activity in inhibiting SARS-CoV-2 replication in vitro, suggesting its potential as a therapy for reducing the duration and severity of COVID-19 in patients, pending further evaluation in ongoing clinical studies. [Read the Full Post]

The role of small GTPases in bisphenol AF-induced multinucleation in comparison with dibutyl phthalate in the male germ cells

178 views | Jun 22 2023

This study demonstrates that BPAF exposure leads to cytotoxicity, increased multinucleation in mouse spermatogonia cells, and highlights the involvement of small GTPase-signaling pathways in mediating these effects, providing insights into the genotoxic mechanisms of BPA analogs on male germ cells. [Read the Full Post]

In vitro target validation and in vivo efficacy of p38 MAP kinase inhibition in established chronic collagen-induced arthritis model: a pre-clinical study

128 views | May 30 2023

The study found that p38 MAPK inhibitors, GW856553X and GSK678361, effectively suppressed murine collagen-induced arthritis, indicating potential therapeutic value for the treatment of RA. [Read the Full Post]

Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trials

71 views | May 30 2023

The proposed methodology for the systematic review appears appropriate for addressing the research question, with a comprehensive search strategy, independent review, network meta-analysis, and quality assessment tools. [Read the Full Post]

Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier

58 views | Mar 31 2023

Targeting the p38 MAPK pathway with selective inhibitors could reduce harmful inflammation and improve current treatment strategies for COVID-19, as suggested by recent findings. [Read the Full Post]