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Genomic and biological aspects of resistance to selective poly(ADP-ribose) glycohydrolase inhibitor PDD00017273 in human colorectal cancer cells

49 views | Sep 04 2023

The study identified specific mutations in PARG and PARP1, resulting in structural modifications and downregulation of PARP1, leading to resistance to the PARG inhibitor PDD00017273 in HCT116RPDD cells. [Read the Full Post]