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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

VDAC

Inhibition of mitochondrial VDAC1 oligomerization alleviates apoptosis and necroptosis of retinal neurons following OGD/R injury

34 views | Oct 26 2023

The study found that inhibiting the oligomerization of Voltage-dependent anion channel 1 (VDAC1) rescues mitochondrial dysfunction and reduces apoptosis/necroptosis in retinal cells, offering a potential therapeutic strategy for ocular diseases caused by ischemia-reperfusion injury. [Read the Full Post]

Microglial VDAC1 signaling modulates sleep deprivation-induced transition to chronic postsurgical pain

90 views | Apr 18 2023

This study demonstrates that sleep deprivation before and after surgery increases the risk of chronic pain by activating spinal microglia, and that VDAC1 signaling regulates microglial activation-related ATP release, inflammation, and pain chronicity in mice. [Read the Full Post]

Congenital sideroblastic anemia model due to ALAS2 mutation is susceptible to ferroptosis

140 views | Jun 05 2022

Koya Ono et al. found that defective heme biosynthesis in XLSA clones could confer enhanced BACH1 expression, leading to increased susceptibility to ferroptosis. [Read the Full Post]

Dihydroquercetin Attenuates Silica-Induced Pulmonary Fibrosis by Inhibiting Ferroptosis Signaling Pathway

206 views | Jun 02 2022

Leyong Yuan et al. found that inhibition of ferritinophagy-mediated HBE cells ferroptosis was responsible for DHQ to ameliorate SiO2-induced lung fibrosis, which provided a preliminary theoretical basis for the clinical application of DHQ in the treatment of silicosis. [Read the Full Post]

Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus

519 views | Jul 15 2021

Wenxin Sha et al. summarized the mechanism of ferroptosis and especially its association with type 2 diabetes mellitus (T2DM). [Read the Full Post]