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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Cysteine Protease

Assessing the venous system: Correlation of mean systemic filling pressure with the venous excess ultrasound grading system in cardiac surgery

63 views | Nov 20 2023

The study demonstrates a strong positive correlation between the venous excess ultrasound (VExUS) grading system and mean systemic filling pressure (Pmsf) in the early postoperative period after cardiac surgery, highlighting the critical role of systemic venous congestion in patient outcomes. [Read the Full Post]

Tenuifolin in the prevention of Alzheimer's disease-like phenotypes: Investigation of the mechanisms from the perspectives of calpain system, ferroptosis, and apoptosis

65 views | Oct 26 2023

Tenuifolin (Ten), an active component of Polygala tenuifolia, prevents Alzheimer's disease (AD)-like phenotypes through multiple mechanisms, including regulation of synaptic plasticity, apoptosis, calcium signaling, oxidative stress, and ferroptosis. [Read the Full Post]

Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B

134 views | Jun 08 2023

The study investigated the pH-dependent inhibitory properties of CA-074, a selective inhibitor of cathepsin B, and found it to be more effective at inhibiting cathepsin B at an acidic pH of 4.6 with nM potency, while maintaining its specificity for cathepsin B over other cysteine cathepsins under both acidic and neutral pH conditions. [Read the Full Post]

Apigenin Alleviated High-Fat-Diet-Induced Hepatic Pyroptosis by Mitophagy-ROS-CTSB-NLRP3 Pathway in Mice and AML12 Cells

86 views | Jun 08 2023

This passage describes a study on the effects of apigenin on liver injury caused by a high-fat diet and palmitic acid-induced pyroptosis in liver cells through the mitophagy-ROS-CTSB-NLRP3 pathway. [Read the Full Post]

DEEMD: Drug Efficacy Estimation Against SARS-CoV-2 Based on Cell Morphology With Deep Multiple Instance Learning

91 views | Jun 07 2023

DEEMD is a computational pipeline using deep neural network models within a multiple instance learning framework to identify putative treatments effective against SARS-CoV-2 based on morphological analysis of the RxRx19a dataset. [Read the Full Post]

Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway

129 views | Jun 07 2023

AS-IV can inhibit hypoxia-induced oxidative stress and apoptosis in hippocampal neurons by downregulating the calpain-1/HIF-1α/caspase-3 pathway. [Read the Full Post]

Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategy

40 views | Jun 06 2023

The study suggests that CTSL could be a promising therapeutic target for COVID-19, and the researchers used Chemprop to identify small molecules and FDA-approved drugs that can block CTSL activity, finding five molecules and drugs that can inhibit the activity of CTSL and inhibit the infection of both pseudotype and live SARS-CoV-2, including daptomycin. [Read the Full Post]

Characterization of a Novel Milk-Clotting Aspartic Protease from Penicillium sp. and Structural Explanation for its High Milk-Clotting Index

138 views | Jun 06 2023

PsMCE is a novel milk-clotting enzyme with specific hydrolysis activity on κ-casein proteins and potential applications in cheese making due to its thermolability and high milk-clotting index value. [Read the Full Post]

Canine distemper virus N protein induces autophagy to facilitate viral replication

93 views | Jun 06 2023

This study revealed that CDV N protein induces complete autophagy to facilitate viral replication, providing new insights into the interaction between CDV and the host autophagy machinery. [Read the Full Post]

Protective Effect of Calpain Inhibition During Cold Ischemia on Ischemia-reperfusion Injury After Lung Transplantation

59 views | Jun 06 2023

The study showed that the administration of ALLN during cold ischemia improves IR lung injury in a lung transplant animal model by suppressing necroptosis. [Read the Full Post]