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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Rho

Rac and Cdc42 inhibitors reduce macrophage function in breast cancer preclinical models

46 views | Dec 16 2023

Rac and Cdc42 inhibitors EHop-016 and MBQ-167 demonstrate dual efficacy by simultaneously targeting metastatic cancer cells and immunosuppressive myeloid cells in the tumor microenvironment, creating an anti-tumor environment in breast cancer. [Read the Full Post]

ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42

34 views | Dec 03 2023

The study reveals that ARHGEF37 upregulation in hepatocellular carcinoma promotes pulmonary metastasis by enhancing tumor cell adhesion to endothelial cells and trans-endothelial migration via direct activation of Cdc42, and targeted inhibition of this pathway using ZCL278 presents a potential therapeutic approach for preventing and treating HCC lung metastasis. [Read the Full Post]

Unique osteogenic profile of bone marrow stem cells stimulated in perfusion bioreactor is Rho-ROCK-mediated contractility dependent

61 views | Sep 14 2023

This study demonstrates that fluid shear stress in a 3D dynamic culture system induces increased actomyosin contractility, upregulation of mechanoreceptors and focal adhesions, and promotes a unique osteogenic profile in bone marrow mesenchymal stem/stromal cells (BMSC), highlighting the importance of mechanical cues in regulating BMSC behavior for potential clinical applications in bone regeneration. [Read the Full Post]

Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation

63 views | Aug 05 2023

The study found that matrix stiffness influences the formation of invasive protrusions in mammary acini, with increased MRTF-A activity observed on stiff matrices, highlighting the intricate interplay between matrix properties and transcription factors in mammary gland development. [Read the Full Post]

Kinesin Family Member C1 Overexpression Exerts Tumor-Promoting Properties in Head and Neck Squamous Cell Carcinoma via the Rac1/Wnt/β-catenin Pathway

89 views | Jul 13 2023

Abnormal upregulation of Kinesin family member C1 (KIFC1) in head and neck squamous cell carcinoma (HNSCC) is regulated by N6-methyladenosine (m6A) RNA methylation via interaction with demethylase alkB homolog 5, promoting HNSCC progression through activation of the Rac1/Wnt/β-catenin pathway. [Read the Full Post]

The role of small GTPases in bisphenol AF-induced multinucleation in comparison with dibutyl phthalate in the male germ cells

178 views | Jun 22 2023

This study demonstrates that BPAF exposure leads to cytotoxicity, increased multinucleation in mouse spermatogonia cells, and highlights the involvement of small GTPase-signaling pathways in mediating these effects, providing insights into the genotoxic mechanisms of BPA analogs on male germ cells. [Read the Full Post]

Identifying the molecular mechanisms of sepsis-associated acute kidney injury and predicting potential drugs

99 views | Jun 11 2023

This study utilized weighted co-expression network analysis, machine learning, immune cell correlation, and drug prediction to identify key ferroptosis genes, potential diagnostic markers, and therapeutic targets, such as miR-650 and miR-296-3p genes, OLFM4, CLU, RRM2, SLC2A3, CCL5, ADAMTS1, and EPHX2, and suggested EHT1864 and salubrinal as potential therapeutic agents for septic acute kidney injury (SA-AKI). [Read the Full Post]

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

41 views | May 06 2023

This passage discusses the identification and characterization of a new Cdc42-selective allosteric inhibitor, which has potential therapeutic implications for diseases related to Cdc42 overactivity and could facilitate molecular pathway studies involving GTPases. [Read the Full Post]

Predictive factors for improvement of symptomatic cerebral vasospasm following subarachnoid hemorrhage by selective intra-arterial administration of fasudil hydrochloride

336 views | Feb 26 2023

Selective intra-arterial administration of fasudil improves neurological findings in 72.2% of patients with cerebral vasospasm following subarachnoid hemorrhage and is most effective when the spasm is limited to peripheral vessels and the patient is younger and does not have a large cerebral infarction in the spasm artery perfusion area. [Read the Full Post]

Endothelial-specific targeting of RhoA signaling via CD31 antibody-conjugated nanoparticles

314 views | Feb 26 2023

The study aimed to develop a CD31-targeting liposome with Fasudil, a clinically-relevant Rho kinase inhibitor, to target the RhoA signaling in endothelial cells for potential anti-angiogenic therapy by minimizing toxicity. [Read the Full Post]