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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Peroxidases

vPIF-1 is an insulin-like antiferroptotic viral peptide

55 views | Jan 28 2024

The study reveals how viral insulin-like peptides, exemplified by LCDV-1 VILP, serve as potent inhibitors of ferroptosis, highlighting their specificity in preventing this form of cell death and suggesting a potential viral defense mechanism in lower organisms. [Read the Full Post]

Identifying responders to elamipretide in Barth syndrome: Hierarchical clustering for time series data

72 views | Sep 23 2023

This proof-of-concept study demonstrated that wearable device data can predict functional status and response to elamipretide treatment in patients with Barth syndrome (BTHS). [Read the Full Post]

Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial

96 views | Sep 23 2023

The MMPOWER-3 trial evaluating the efficacy of elamipretide in individuals with Primary Mitochondrial Myopathies did not show significant improvements in physical function and fatigue but established the drug's safety and tolerability. [Read the Full Post]

The Multidrug Resistance Transporter P-glycoprotein Confers Resistance to Ferroptosis Inducers

125 views | Apr 26 2023

The study investigates the interaction of small molecule ferroptosis inducers with ABC transporters, specifically P-glycoprotein and ABCG2, highlighting their potential role in limiting bioavailability and brain penetration of these inducers and predicting drug-drug interactions. [Read the Full Post]

Factors contributing to the utilization of robotic colorectal surgery: a systematic review and meta-analysis

58 views | Dec 17 2022

Dana M Hayden et al. identifies nonclinical disparities in access to robotics that should be addressed to provide more equitable access to innovations in colorectal surgery. [Read the Full Post]

Acid-Responsive Micelles Releasing Cinnamaldehyde Enhance RSL3-Induced Ferroptosis in Tumor Cells

161 views | Jun 06 2022

Ziliang Yan et al. confirmed that RSL3@PCA has excellent inhibition of tumor growth without significant toxicity to normal cells and tissues and still has a good therapeutic effect on tumor cells that are resistant to conventional chemotherapy drugs. [Read the Full Post]

TGF-β1-mediated Repression of SLC7A11 Drives Vulnerability to GPX4 Inhibition in Hepatocellular Carcinoma Cells

499 views | Jun 09 2020

Do Hyung Kim et al. showed that TGF-β1 repressed xCT expression via Smad3 activation and enhanced lipid peroxidation in hepatocellular carcinoma cells with an early TGF-β1 signature, which would benefit from the targeting of GPX4. [Read the Full Post]