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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Complement System

Leukadherin-1 inhibits NLRP3 inflammasome by blocking inflammasome assembly

72 views | Jan 15 2024

Leukadherin-1 (LA-1) demonstrates potent inhibition of NLRP3 inflammasome activation through specific mechanisms, suggesting its potential as a targeted treatment for NLRP3-associated inflammatory diseases. [Read the Full Post]

Complement C3a receptor antagonist alleviates tau pathology and ameliorates cognitive deficits in P301S mice

55 views | Nov 18 2023

The study reveals that upregulation of C3aR in tauopathy mouse models leads to tau hyperphosphorylation and behavioral deficits, and pharmacological blockade of C3aR not only ameliorates these pathological features but also improves synaptic integrity, suggesting C3aR as a promising therapeutic target for neurodegenerative diseases like Alzheimer's. [Read the Full Post]

Treatment of eculizumab refractory paroxysmal nocturnal hemoglobinuria: A systematic review about current treatment options and future direction

40 views | Oct 28 2023

The systematic review highlights the need for individualized treatment plans and further research to evaluate the efficacy of different medications in managing eculizumab refractory Paroxysmal Nocturnal Hemoglobinuria (PNH). [Read the Full Post]

Complement dependent TNFα production in neutrophil-like HL60 cells

104 views | Aug 08 2023

This study demonstrates that complement C3 activation mediates TNFα production in neutrophil-like HL60 cells, which is enhanced by intracellular calcium elevation and negatively regulated by interactions with fibrinogen or fibronectin. [Read the Full Post]

16a-Methyl corticosteroids; a new series of anti-inflammatory compounds; clinical appraisal of their antirheumatic potencies

146 views | Feb 16 2023

Four new derivatives of hydrocortisone with a methyl grouping at the 16a-carbon position were synthesized and studied in human subjects for anti-inflammatory activity, with 16a-methyl 9a-fluoroprednisolone showing the highest potency per milligram and potential for long-term therapeutic use. [Read the Full Post]

Allolobophora caliginosa coelomic fluid and extract alleviate glucocorticoid-induced osteoporosis in mice by suppressing oxidative stress and regulating osteoblastic/osteoclastic-related markers

187 views | Feb 16 2023

This study investigated the chemo-preventive activity of A.calignosa coelomic fluid and extract on glucocorticoid-induced osteoporosis in mice, revealing that both showed chemo-preventive activity by inhibiting oxidative stress and regulating expression and activity of osteoblast/osteoclast-related markers, resulting in increased bone mineral density and decreased activity of alkaline phosphatase and parathyroid hormone. [Read the Full Post]

Dual Delivery of Cyclosporin A and Etodolac Using Polymeric Nanocapsules in a Rabbit Eye Model: Ocular Biodistribution and Pharmacokinetic Study

90 views | Nov 11 2022

Syed Nazrin Ruhina Rahman et al. thought that the biodistribution and pharmacokinetic data might help and strengthen their understanding of synergetic anti-inflammatory activity of CsA and Edc from nanocapsules after its ocular topical application for managing keratoconjunctivitis sicca. [Read the Full Post]

Cannabidiol Inhibits In Vitro Human Liver Microsomal Metabolism of Remdesivir: A Promising Adjuvant for COVID-19 Treatment

461 views | Dec 19 2021

Aishwarya Saraswat et al. suggested that CBD significantly inhibited human liver microsomal metabolism of RDV and extended its in vitro half-life. [Read the Full Post]