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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

MLCK

Alignment of actin filament streams driven by myosin motors in crowded environments

56 views | Feb 06 2024

In a crowded cellular environment, the interplay between myosin-driven actin filament movement and ionic strength unveils a remarkable spatial patterning, offering profound insights into cytoskeletal organization within living cells. [Read the Full Post]

Bone impact after two years of low-dose oral contraceptive use during adolescence

184 views | Sep 29 2023

The present study indicates that the use of combined hormonal contraceptives in healthy adolescents is associated with compromised bone mass acquisition, with a more pronounced negative impact observed in those using contraceptives containing 30 μg of Ethinylestradiol. [Read the Full Post]

Effect of chronopharmacology and food on in vivo pharmacokinetic profile of mavacamten

112 views | Sep 03 2023

This study found that circadian rhythms significantly impact the pharmacokinetics of mavacamten in rats, while food intake has a minimal effect, highlighting the importance of considering chronopharmacology in optimizing dosing time for this drug. [Read the Full Post]

Current and emerging pharmacotherapy for the management of hypertrophic cardiomyopathy

101 views | Sep 03 2023

The emerging cardiac myosin inhibitors (CMIs) and ongoing research into targeted therapies and gene therapy hold promise for improving the management and treatment of hypertrophic cardiomyopathy (HCM). [Read the Full Post]

Predictive factors for improvement of symptomatic cerebral vasospasm following subarachnoid hemorrhage by selective intra-arterial administration of fasudil hydrochloride

336 views | Feb 26 2023

Selective intra-arterial administration of fasudil improves neurological findings in 72.2% of patients with cerebral vasospasm following subarachnoid hemorrhage and is most effective when the spasm is limited to peripheral vessels and the patient is younger and does not have a large cerebral infarction in the spasm artery perfusion area. [Read the Full Post]

Endothelial-specific targeting of RhoA signaling via CD31 antibody-conjugated nanoparticles

314 views | Feb 26 2023

The study aimed to develop a CD31-targeting liposome with Fasudil, a clinically-relevant Rho kinase inhibitor, to target the RhoA signaling in endothelial cells for potential anti-angiogenic therapy by minimizing toxicity. [Read the Full Post]