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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Adrenergic Receptor

Ecological benefits of artificial light at night (ALAN): Accelerating the development and metamorphosis of marine shellfish larvae

98 views | Feb 10 2024

The comprehensive study on artificial light at night (ALAN) reveals a surprising positive impact of short-wavelength blue light on Pacific abalone embryonic development, offering crucial insights into the differential effects of light spectrums and their implications for marine benthic ecosystems. [Read the Full Post]

Sibutramine-Induced Nonischemic Cardiomyopathy

83 views | Feb 09 2024

The case report of sibutramine-induced nonischemic cardiomyopathy in a young individual underscores the critical need for safer anti-obesity medications and vigilant patient monitoring to mitigate severe cardiovascular risks associated with pharmacotherapy. [Read the Full Post]

Theophylline-induced endothelium-dependent vasodilation is mediated by increased nitric oxide release and phosphodiesterase inhibition in rat aorta

69 views | Dec 06 2023

Theophylline-induced endothelium-dependent vasodilation in isolated rat thoracic aortas is mediated by increased endothelial nitric oxide release, guanylate cyclase activation, elevated cGMP levels, and enhanced endothelial nitric oxide synthase phosphorylation. [Read the Full Post]

High-intensity interval training improves fatty infiltration in the rotator cuff through the β3 adrenergic receptor in mice

80 views | Nov 25 2023

High-Intensity Interval Training (HIIT) improved muscle quality in a rotator cuff tear model by activating the β3 adrenergic receptor pathway, enhancing supraspinatus muscle function, and reducing atrophy and fatty infiltration. [Read the Full Post]

Divergent splanchnic sympathetic efferent nerve pathways regulate interleukin-10 and tumour necrosis factor-α responses to endotoxaemia

136 views | Jul 19 2023

This study demonstrates that the splanchnic sympathetic nerves mediate an endogenous neural reflex that enhances interleukin-10 levels and suppresses tumor necrosis factor-α levels in response to systemic immune challenge, with distinct pathways regulating these cytokine responses. [Read the Full Post]

Randomised, prospective, blinded, clinical trial of opioid-free injectable anaesthesia with or without multimodal analgesia in kittens undergoing ovariohysterectomy

105 views | Apr 27 2023

This study found that an opioid-free injectable anaesthetic protocol with multimodal analgesia provided effective pain relief and reduced the need for rescue analgesia in kittens undergoing ovariohysterectomy, while also observing a decrease in food intake due to pain. [Read the Full Post]

A 2023 update on the advancements in the treatment of agitation in Alzheimer's disease

149 views | Apr 16 2023

Recent advances in the understanding of neurobiological mechanisms of agitation in Alzheimer's Disease have led to the identification of several agents with promise for treating agitation, and clinical trials are underway to develop safe and efficacious treatment options. [Read the Full Post]

Pharmacokinetic and Pharmacodynamic Comparison of Fluticasone Propionate/Formoterol Fumarate Administered via a Pressurized Metered-Dose Inhaler and a Novel Breath-Actuated Inhaler in Healthy Volunteers

93 views | Mar 13 2023

The passage describes the results of two studies comparing the exposure of fluticasone/formoterol following administration via BAI with pMDI with/without a spacer in healthy volunteers, which showed that BAI performance was comparable to pMDI and systemic safety with BAI was no worse than the primary comparator. [Read the Full Post]

Experimental observation of human bone marrow mesenchymal stem cell transplantation into rabbit intervertebral discs

1272 views | Sep 30 2018

Tao H et al. indicated that in the sections of specimens removed at 1, 2, 4, 6 and 8 weeks post-transplantation, no GFP-positive cells were observed in the control groups, whereas GFP-positive cells were apparent in the nucleus pulposus at all periods in the GFP-labeled human BMSCs group, and the cell density at 6 and 8 weeks was significantly less than that at 1, 2 and 4 weeks post-transplantation (P<0.001). [Read the Full Post]

Evaluation of cardioprotective effect of aqueous extract of Garcinia indica Linn. fruit rinds on isoprenaline-induced myocardial injury in Wistar albino rats

1433 views | Apr 18 2018

Patel KJ et al. found that the aqueous extract of G. indica was not found to be cardioprotective against myocardial injury. [Read the Full Post]