Choose Your Country or Region

Category

PI3K/Akt/mTOR
- PI3K
- mTOR
- Akt
- GSK-3
- ATM/ATR
- PDK
- AMPK
- DNA-PK
- PTEN
- MELK
- PP2A
- PIKfyve
- PI4K
- PDPK1
Epigenetics
- HDAC
- AMPK
- PARP
- JAK
- Pim
- HIF
- PKC
- Aurora Kinase
- Sirtuin
- DNA Methyltransferase
- Histone Acetyltransferase
- Epigenetic Reader Domain
- Histone Methyltransferase
- Histone Demethylase
- SETD
- NSD
- G9a/GLP
- FTO
- MLL
- MicroRNA
- JMJD
- PRMT
- EZH1/2
- PAD
- LSD1
- COMT
- SAM MTase
- PPMTase
- WDR5
- SMYD
- DOT1
- HNMT
Methylation
- DNA Methyltransferase
- NNMT
- COMT
- SAM MTase
- PPMTase
- WDR5
- SMYD
- DOT1
- HNMT
- SETD
- G9a/GLP
- MLL
- JMJD
- PRMT
- EZH1/2
- NSD
- FTO
- LSD1
- MAT2A
Immunology & Inflammation
- CD markers
- PD-1/PD-L1
- TNF-alpha
- COX
- CCR
- Histamine Receptor
- IL Receptor
- Nrf2
- ROS
- NADPH-oxidase
- Anti-infection
- AhR
- IDO/TDO
- gp120/CD4
- NOD
- CXCR
- MALT
- LTR
- TLR
- NOS
- Immunology & Inflammation related
- Pyroptosis
- NLRP3
- Neuraminidase
- cGAS
- PGDS
- SIK
- TRIF
- FKBP
- PKR
- AKR1C
- Parasite
- TpoR
- MmpL3
- Heme Oxygenase
- Antioxidant
- MyD88
- eIF
- MIF
- STING
- Nur77
- Galectin
- Complement System
- Prostaglandin Receptor
- SPHK
- Glutathione
- PGES
- β-lactamase
- IFN
- TBK1
- FLAP
- IRAK
- Arginase
- Interleukins
Protein Tyrosine Kinase
- VEGFR
- MEK
- EGFR
- PDGFR
- c-Met
- HER2
- IGF-1R
- FLT3
- FGFR
- Bcr-Abl
- c-Kit
- Src
- ALK
- Syk
- Tie-2
- FAK
- c-RET
- Ephrin receptor
- CSF-1R
- ACK
- Trk receptor
- BTK
- DYRK
- RON
- Fer kinase
- ETK/BMX
- Mertk
- Axl
- Tyro3
- Pyk2
- ROS1
- DDR
Angiogenesis
- VEGFR
- JAK
- EGFR
- PDGFR
- HER2
- FLT3
- FGFR
- HIF
- VDA
- Bcr-Abl
- Src
- ALK
- Syk
- FAK
- BTK
Apoptosis
- PD-1/PD-L1
- STAT
- Bcl-2
- Caspase
- p53
- TNF-alpha
- MDM2/MDMX
- Survivin
- Ras
- c-RET
- IAP
- RIP kinase
- PERK
- ASK
- Ferroptosis
- Myc
- PFKFB
- cytohesin
- FKBP
- Apoptosis related
- OXPHOS
- Heme Oxygenase
- TRADD
- Bcl-6
- Thymidylate Synthase
- Pyroptosis
- DAPK
- Nur77
- PKD
Autophagy
- CXCR
- Nrf2
- LRRK2
- Autophagy
- OGA
- Beclin
- LC3
- cGAS
- ULK
- FKBP
- Mitophagy
- Heme Oxygenase
ER stress & UPR
- JNK
- HSP (HSP90)
- ROS
- PERK
- ASK
- eIF
- PKR
- Antioxidant
- ATF-6
- PDI
- IRE1
JAK/STAT
- JAK
- STAT
- EGFR
- Pim
MAPK
- S6 Kinase
- MEK
- Raf
- p38 MAPK
- JNK
- Ras
- TOPK
- ASK
- Mixed Lineage Kinase
- MNK
- KLF
- TAK1
- ERK
- MAP4K
- MAPKAPK2
Cytoskeletal Signaling
- Akt
- Bcr-Abl
- Wnt/beta-catenin
- PKC
- FAK
- HSP (HSP90)
- Kinesin
- ROCK
- Microtubule Associated
- MPS1
- Dynamin
- PAK
- Integrin
- Gap-Junction
- MLCK
- Actin
- Cardiac Myosin
- PORCN
- TACC3
Cell Cycle
- CDK
- DNA/RNA Synthesis
- PD-1/PD-L1
- Ras
- Aurora Kinase
- HSP (HSP90)
- Kinesin
- Chk
- ROCK
- Microtubule Associated
- DHFR
- PLK
- APC
- Wee1
- TOPK
- Myc
- Serine/threonin kinase
- PAK
- Rho
- MPS1
- DYRK
- Casein Kinase
- PERK
- Mad2
- Haspin Kinase
- Choline kinase
- AP-1
- BMI-1
- DOCK
- p21
- FOXM1
- eIF
- Nur77
- TACC3
- PP2A
- RUNX
- PFKFB
- LIM kinase
TGF-beta/Smad
- TGF-beta/Smad
- Bcr-Abl
- PKC
- ROCK
DNA Damage/DNA Repair
- HDAC
- ATM/ATR
- PARP
- DNA/RNA Synthesis
- PPAR
- MDM2/MDMX
- Sirtuin
- Topoisomerase
- DNA-PK
- DHFR
- Telomerase
- High-mobility Group
- DNA alkylator
- MTH1
- Casein Kinase
- G-quadruplex
- RNR
- NUDIX
- eIF
- SMN
- Nucleoside Analog/Antimetabolite
- LIM kinase
- RAD51
- CRISPR/Cas9
- BMI-1
- Pax
- FENs
- OGG1
- Thymidylate Synthase
Stem Cells & Wnt
- GSK-3
- JAK
- STAT
- TGF-beta/Smad
- Wnt/beta-catenin
- ROCK
- Hedgehog/Smoothened
- PKA
- Stemness kinase
- KLF
- OCT
- Casein Kinase
- ERK
- SFRP
- Fascin
- PORCN
- Notch
- Secretase
Hippo
- LATS
- TEAD
- MAP4K
- MST
- YAP
Ubiquitin
- Proteasome
- DUB
- p97
- E1 Activating
- SUMO
- E2 conjugating
- E3 Ligase
Neuronal Signaling
- Calcium Channel
- Beta Amyloid
- 5-HT Receptor
- COX
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GABA Receptor
- P-gp
- P2 Receptor
- Cannabinoid Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- MAO
- FAAH
- BACE
- Trk receptor
- GlyT
- NMDAR
- CaMK
- Notch
- Imidazoline Receptor
- Sigma Receptor
- NPY receptor
- Serotonin Transporter
- CCK receptor
- Neurotensin Receptor
- COMT
- Melanocortin Receptor
- Adenosine Deaminase
- TRP Channel
- Adenosine Kinase
- BChE
- EAAT
- Neurokinin Receptor
NF-κB
- HDAC
- NF-κB
- IκB/IKK
- MALT
- Nrf2
- ROS
- NOD
- Antioxidant
- AP-1
GPCR & G Protein
- Ras
- 5-HT Receptor
- CCR
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GPR
- P2 Receptor
- Cannabinoid Receptor
- Endothelin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- SGLT
- LPA Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- PAFR
- PKA
- Adenosine Receptor
- Vasopressin Receptor
- cAMP
- CXCR
- TAAR
- CaSR
- Glucagon Receptor
- LTR
- Parathyroid Hormone Receptor
- NPY receptor
- DOCK
- AdipoR
- GPCR19
- Guanylate Cyclase
- GHSR
- CCK receptor
- FPR
- GRK
- Leukotriene
- Prostaglandin Receptor
- PKD
- TSH Receptor
- Neurokinin Receptor
- GNRH Receptor
- CRFR
- PKG
- Bradykinin Receptor
- Angiotensin Receptor
- Bombesin Receptor
- Imidazoline Receptor
- Neurotensin Receptor
- RGS
- Melanocortin Receptor
- Sigma Receptor
- Taste Receptor
- PAR
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
- Glucocorticoid Receptor
- THR
- ACE
- SSTR
- GHSR
- CCK receptor
- PGES
- TSH Receptor
- GNRH Receptor
- PGDS
- Mineralocorticoid Receptor
Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
- AChR
- GABA Receptor
- P-gp
- Proton Pump
- CFTR
- P2 Receptor
- SGLT
- GLUT
- GlyT
- NMDAR
- OCT
- CRM1
- MCT
- Amino acid transporter
- OAT
- Mechanosensitive Channel
- BCRP
- NKCC
- NCX
- TRP Channel
- OATP
- VRAC
- Aquaporin
- EAAT
- VDAC
- MTP
- VMAT
- GlyR
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
- Carbonic Anhydrase
- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- Serine/threonin kinase
- CETP
- IDO/TDO
- phosphatase
- GLUT
- HMG-CoA Reductase
- Vitamin
- PKM
- Lipoxygenase
- FOX
- Lipase
- Fatty Acid Synthase
- LDL
- NAMPT
- Decarboxylase
- Casein Kinase
- Thioredoxin
- Retinoid Receptor
- Transferase
- FXR
- Neprilysin
- PP2A
- FTO
- RUNX
- SREBP
- AdipoR
- PAD
- CPT
- SCD
- CAR
- AP-1
- LDH
- Carbohydrate Metabolism
- γGCS
- SSTR
- PAI-1
- FTase
- SOD
- ATP-citrate lyase
- FAO
- SGK
- GOT
- 3-MST
- GTPCH
- glucocerebrosidase
- FABP
- Serine hydrolase
- Epoxide Hydrolase
- ACSS2
- ROR
- Catalase
- THR
- PDHK
- Glucosylceramide Synthase
- ACE
- Thioredoxin Reductase
- PGC-1α
- PARG
- Xanthine Oxidase
- Mannosidase
- Leukotriene
- Adenosine Deaminase
- Aldose Reductase
- CPSase
- Acetyl-CoA carboxylase
- Adenosine Kinase
- OXPHOS
- Glutathione
- PCSK9
- Mitochondrial Metabolism
- Peroxidases
- SHIP
- PGDS
- Mitochondrial pyruvate carrier
- PREP
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- MALT
- Glutaminase
- Tyrosinase
- Serine Protease
- Cysteine Protease
- PAD
- PCSK9
- Secretase
- Cathepsin B
- PGDS
- Neprilysin
- SGK
- PREP
- GOT
- 3C-Like Protease
Microbiology
- HCV Protease
- Integrase
- Reverse Transcriptase
- HIV Protease
- Anti-infection
- Fungal
- CMV
- Neuraminidase
- Parasite
- Antiviral
- Thioredoxin Reductase
- Bacterial
- β-lactamase
- Antibiotics
- 3C-Like Protease
- Enterovirus
- COVID-19
- Influenza Virus
- Ribosomal Peptidyl Transferase
- SARS-CoV
- RSV
- HPV
- HSV
- HCV
- HBV
- HIV
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

Archives

Popular Post

ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

RNR

Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production

132 views | Oct 26 2023

In this study, the increased expression of ribonucleotide reductase regulatory subunit M2 (RRM2) and its regulation of dGTP and dCTP production during temozolomide (TMZ) therapy were identified as key factors in driving chemoresistance in glioblastoma (GBM), and treatment with the RRM2 inhibitor 3-AP (Triapine) improved the efficacy of TMZ therapy in patient-derived xenograft (PDX) models. [Read the Full Post]

Purine Antimetabolites associated Pneumocystis Jiroveci Pneumonia

174 views | Oct 20 2023

The retrospective disproportionality analysis of the FDA Adverse Event Reporting System (FAERS) database revealed a significant safety signal for pneumocystis jiroveci pneumonia (PJP) associated with purine antimetabolites, particularly fludarabine and thioguanine, among populations with autoimmune disorders and cancer. [Read the Full Post]