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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

ROS

Effects of staged multiple phytohormones application on capillary-driven attached Chlorella sp. biofilm

115 views | Feb 13 2024

This study explores the synergistic effects of combining low concentrations of 6-benzylaminopurine and salicylic acid in microalgae cultivation for enhanced growth, antioxidative response, and efficient nutrient removal in wastewater treatment systems. [Read the Full Post]

iTRAQ-based quantitative proteomic analysis of the antibacterial mechanism of silver nanoparticles against multidrug-resistant Streptococcus suis

104 views | Jan 04 2024

The study elucidates that silver nanoparticles disrupt the morphology, inhibit key cellular processes, induce oxidative stress, and potentially interfere with biofilm formation in multidrug-resistant Streptococcus suis, proposing a multifaceted antibacterial mechanism. [Read the Full Post]

Fabrication and characterization of dihydromyricetin-loaded microcapsules stabilized by glyceryl monostearate and whey protein-xanthan gum

167 views | Jan 02 2024

Encapsulation of dihydromyricetin using glyceryl monostearate and octyl/decyl glycerate as inner cores, whey protein, and xanthan gum as wall materials demonstrated enhanced stability, controlled release, and improved antioxidant effects, presenting a promising strategy for delivering lipophilic bioactive compounds with heightened bioavailability and stability. [Read the Full Post]

Active Components of Leontopodium alpinum Callus Culture Extract for Blue Light Damage in Human Foreskin Fibroblasts

253 views | Dec 31 2023

Research on Leontopodium alpinum callus culture extract's components, particularly leontopodic acid A, reveals promising potential in protecting skin cells from blue light damage, offering avenues for future skincare and pharmaceutical developments. [Read the Full Post]

Identification of upregulated genes in glioblastoma and glioblastoma cancer stem cells using bioinformatics analysis

169 views | Dec 29 2023

This comprehensive study uncovered potential therapeutic targets for glioblastoma by identifying highly coexpressed genes in cancer stem cells, highlighting DUSP6 and SOX2 as prognostically relevant hub genes and proposing (E/Z)-BCI and BCI compounds as promising anti-cancer agents via strong binding interactions with DUSP6's ERK2 binding domain. [Read the Full Post]

Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models

198 views | Dec 07 2023

The study demonstrates that ABTL0812, an oral anticancer compound, inhibits GBM cell proliferation, reverses proneural to mesenchymal transition, induces cell differentiation, and promotes autophagy-mediated cell death, providing compelling evidence for its potential as a novel therapy, either alone or in combination with standard treatments, for glioblastoma multiforme. [Read the Full Post]

Human phytanoyl-CoA dioxygenase domain-containing 1 (PHYHD1) is a putative oxygen sensor associated with RNA and carbohydrate metabolism

78 views | Nov 27 2023

PHYHD1, a 2-oxoglutarate-dependent dioxygenase, exhibits inhibitory interactions with succinate and fumarate, activation by citrate, binds mRNA, and is localized in both the nucleus and cytoplasm, implicating it as a potential oxygen sensor and linking it to diverse cellular processes including cell division, RNA metabolism, and carbohydrate metabolism. [Read the Full Post]

Apolipoprotein E polymorphism impacts white matter injury through microglial phagocytosis after experimental subarachnoid hemorrhage

110 views | Sep 14 2023

The study found that the APOE4 allele significantly worsened white matter injury and impaired microglial phagocytosis after subarachnoid hemorrhage, suggesting that targeting oxidative stress and promoting phagocytosis could be potential therapeutic strategies for managing this condition. [Read the Full Post]

Effects of mitoquinone (MitoQ) supplementation during boar semen cryopreservation on sperm quality, antioxidant status and mitochondrial proteomics

176 views | Sep 14 2023

Supplementation of boar semen extender with 10 μM MitoQ during cryopreservation improves sperm quality by enhancing antioxidant capacity and regulating mitochondrial proteins associated with motility and energy metabolism. [Read the Full Post]

Increased NOX2 expression in astrocytes leads to eNOS uncoupling through dihydrofolate reductase in endothelial cells after subarachnoid hemorrhage

119 views | Sep 13 2023

Increased NOX2 expression in astrocytes after subarachnoid hemorrhage leads to eNOS uncoupling, exacerbating acute vasoconstriction and cerebral ischemia. [Read the Full Post]