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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Histone Acetyltransferase

Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer

47 views | Jan 20 2024

CTx-648, a highly potent and selective KAT6A/KAT6B inhibitor, demonstrates significant anti-tumor activity in ER-positive breast cancer models, including those resistant to endocrine therapy, showing promise for targeting KAT6A in this context. [Read the Full Post]

In Silico Study on the Interactions, Molecular Docking, Dynamics and Simulation of Potential Compounds from Withania somnifera (L.) Dunal Root against Cancer by Targeting KAT6A

39 views | Jan 01 2024

The study on Withania somnifera compounds demonstrates promising anticancer potential through molecular interactions with KAT6A and validated inhibitory effects on human breast cancer cells, validating the traditional use of W. somnifera as an effective anticancer herb. [Read the Full Post]

Ginkgolic acid inhibits the replication of pseudorabies virus in vitro and in vivo by suppressing the transcription of viral late genes

89 views | Nov 22 2023

Ginkgolic acid has been identified as a potent inhibitor of pseudorabies virus (PRV) replication by specifically suppressing the transcription of PRV late genes, offering a promising therapeutic avenue for combating PRV infections in the swine industry. [Read the Full Post]

Androgen Receptor Variants Confer Castration Resistance in Prostate Cancer by Counteracting Antiandrogen-Induced Ferroptosis

64 views | Nov 19 2023

The passage discusses how acute treatment with the antiandrogen enzalutamide induces ferroptosis in prostate cancer cells by decreasing glutathione production, increasing lipid peroxidation, and upregulating the cystine transporter gene SLC7A11 through both full-length and variant forms of the androgen receptor, revealing a potential mechanism for therapeutic resistance and identifying a target for intervention. [Read the Full Post]

Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia

66 views | Oct 09 2023

Defective cell cycle arrest, particularly involving downregulation of CDKN2A, is a clinically significant contributor to chemoresistance in acute myeloid leukemia (AML), and therapeutic combinations targeting the G1S cell cycle restriction point and promoting apoptosis show promise in enhancing treatment response and potentially overcoming chemoresistance. [Read the Full Post]

The histone acetyltransferase Mof regulates Runx2 and Osterix for osteoblast differentiation

40 views | Oct 08 2023

The study reveals that the histone acetyltransferase Mof functions as a novel regulator of osteoblast differentiation by promoting the expression of osteogenic markers Runx2 and Osterix, suggesting its potential as a therapeutic target for conditions like osteosarcoma and osteoporosis. [Read the Full Post]

Intraoperative Fluorescein Angiography Can Efficiently Identify Biomarkers And Guide Surgical Decision Making

65 views | Aug 23 2023

This study presents an efficient method for performing fluorescein angiography during Digitally Assisted Vitreoretinal Surgery, enabling real-time visualization and intervention by modifying the accessory light sources and utilizing digital imaging software. [Read the Full Post]

NAT10 Drives Cisplatin Chemoresistance by Enhancing ac4C-Associated DNA Repair in Bladder Cancer

45 views | Jun 19 2023

The study reveals that the RNA modification ac4C, mediated by NAT10, promotes cisplatin chemoresistance in bladder cancer by enhancing DNA damage repair through stabilization of AHNAK mRNA, and targeting NAT10 could be a potential therapeutic approach to overcome cisplatin resistance in bladder cancer. [Read the Full Post]

UPP1 Promotes Lung Adenocarcinoma Progression through Epigenetic Regulation of Glycolysis

55 views | May 31 2023

This study characterized the function and underlying mechanisms of Uridine phosphorylase 1 (UPP1) in mediating the progression of Lung Adenocarcinoma (LUAD) cells, confirming it as a novel oncogene and a potential therapeutic target for LUAD. [Read the Full Post]

Effect of hybrid compounds of stilbene and pentadienone on inhibition of tubulin polymerization

254 views | Mar 09 2023

The study designed and synthesized hybrid compounds with excellent anticancer properties that inhibit tubulin polymerization and induce cell cycle arrest in MDA-MB-231 human breast cancer cells. [Read the Full Post]