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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Carbohydrate Metabolism

A pro-death autophagy-based nanoplatform for enhancing antitumour efficacy with improved immune responses

43 views | Jan 20 2024

The innovative CS-3BP/PA@DOX nanoplatform demonstrates promising potential by leveraging pro-death autophagy, immune modulation, and chemotherapeutic strategies to comprehensively target the tumor microenvironment and enhance anti-tumor efficacy while offering a new therapeutic direction through 3-bromopyruvic acid (3BP) in cancer treatment. [Read the Full Post]

Validation of a highly sensitive HaloTag-based assay to evaluate the potency of a novel class of allosteric β-Galactosidase correctors

31 views | Jan 11 2024

SEE-Tx® technology identified STAR compounds that effectively enhanced the transport and activity of β-galactosidase enzymes, showcasing promise for treating lysosomal storage disorders associated with GLB1 mutations. [Read the Full Post]

Glucose induced-AKT/mTOR activation accelerates glycolysis and promotes cell survival in acute myeloid leukemia

97 views | Apr 28 2023

The study found that glucose-induced AKT/mTOR activation promotes AML growth and inhibition of glycolysis may be a potential therapy strategy for AML. [Read the Full Post]

Positron Emission Tomography Imaging in Vasculitis

142 views | Apr 27 2023

FDG-PET/CT is an important imaging tool in the diagnosis and therapeutic monitoring of vasculitides affecting large-sized and medium-sized vessels, and with advancements in newer generation scanners and development of novel tracers, it has shown significant potential in accurately assessing the full disease extent and detecting vascular infiltrates. [Read the Full Post]

Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases

68 views | Mar 26 2023

The study found that LND is a broad-spectrum inflammasome inhibitor that directly targets ASC and may have potential as a therapeutic agent for inflammasome-driven diseases in clinic. [Read the Full Post]

A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma

89 views | Mar 26 2023

The proposed chemotactic nanomotor loaded with brain endothelial cell targeting agent angiopep-2 and anti-tumor drug TLND, which uses ROS/iNOS as chemoattractants to induce the chemotactic behavior, has the potential to overcome major challenges of immunotherapy for glioblastoma and enhance the immune response against the tumor while preventing recurrence. [Read the Full Post]

A new series of hydrazones as small-molecule aldose reductase inhibitors

106 views | Mar 13 2023

The study reports the design, synthesis, and evaluation of tetrazole-hydrazone hybrids as aldose reductase inhibitors, identifying compound 4 as the most potent and safe inhibitor for further in vivo studies. [Read the Full Post]

Effect of Pre-Meal Metformin With or Without an Acute Exercise Bout on Postprandial Lipemic and Glycemic Responses in Metabolic Syndrome Patients: A Randomized, Open Label, Crossover Study

237 views | Mar 12 2023

Pre-meal metformin administration 30 minutes prior to the meal has favorable effects on postprandial total cholesterol and LDL-cholesterol levels compared to its administration with the meal, and the addition of one exercise bout only improves postprandial glycemia and insulinemia in metabolic syndrome patients. [Read the Full Post]

mbined use of metformin and atorvastatin attenuates atherosclerosis in rabbits fed a high-cholesterol diet

567 views | Mar 13 2020

Luo F et al. suggested that atorvastatin/metformin combination therapy may achieve additional anti-atherosclerotic benefits likely through increasing cholesterol efflux in macrophages. [Read the Full Post]