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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

STING

Porphyromonas gingivalis induces an inflammatory response via the cGAS-STING signaling pathway in a periodontitis mouse model

55 views | Jan 25 2024

The study illustrates that the cGAS-STING signaling pathway is pivotal in mediating the inflammatory response induced by Porphyromonas gingivalis, potentially offering a promising target for managing chronic periodontitis. [Read the Full Post]

Putative nucleotide-based second messengers in archaea

47 views | Dec 06 2023

Nucleotide-based second messengers in archaea, including cyclic di-AMP and cyclic oligoadenylates, have been identified with specific roles in osmoregulation and Type III CRISPR-Cas defense, while other putative second messengers await further characterization, highlighting the complexity of cellular signaling in these organisms. [Read the Full Post]

A sequential scheme including PTT and 2'3'-cGAMP/CQ-LP reveals the antitumor immune function of PTT through the type I interferon pathway

48 views | Nov 19 2023

The study elucidates the mechanisms underlying Photothermal Therapy (PTT) by demonstrating STING-dependent and STING-independent type I interferon production, and proposes a synergistic approach using a novel liposome co-loaded with the STING agonist cGAMP and chloroquine, which, when combined with PTT, induces significant tumor cell apoptosis and modulates the tumor microenvironment, providing crucial insights for the rational design of potent antitumor combination treatments. [Read the Full Post]

Sono-Driven Sting Activation Using Semiconducting Polymeric Nanoagonists For Precision Sono-Immunotherapy of Head And Neck Squamous Cell Carcinoma

49 views | Sep 19 2023

This study presents a novel approach utilizing a semiconducting polymeric nanoagonist activated by ultrasound to trigger immunogenic cell death, release a STING agonist, and promote antitumor immunity for precise and effective treatment of head and neck squamous cell carcinoma. [Read the Full Post]

The Microtubule Destabilizer Eribulin Synergizes with STING Agonists to Promote Antitumor Efficacy in Triple-Negative Breast Cancer Models

56 views | Sep 16 2023

Eribulin, a microtubule destabilizer used in the treatment of triple-negative breast cancer, has been found to enhance interferon beta expression and innate immune sensing pathways when combined with STING agonists, suggesting its potential as an immune adjuvant in combination with immunotherapies for more effective treatment of TNBC and other malignancies. [Read the Full Post]

MEK inhibition sensitizes pancreatic cancer to STING agonism by tumor-cell intrinsic amplification of type I interferon signaling

113 views | Aug 28 2023

MEK inhibitors synergistically enhance the cytotoxic effects of STING agonists on pancreatic ductal adenocarcinoma (PDAC) cells by suppressing NF-κB activation and promoting Type I interferon-dependent cell death. [Read the Full Post]

Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells

119 views | Jun 06 2023

The study found that overexpression of IRAK1 in glioma patients is associated with a poor prognosis, and that IRAK1 knockdown inhibits malignancy and enhances radiosensitivity by targeting the IRAK1-PRDX1 axis. [Read the Full Post]

Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis

60 views | May 08 2023

Licorice extract may have therapeutic potential for non-alcoholic steatohepatitis by inhibiting the cGAS-STING pathway and improving hepatic inflammation and fibrosis. [Read the Full Post]

PHLPP1 regulates PINK1-parkin signalling and life span

97 views | May 08 2023

PHLPP1 regulates mitochondrial homeostasis by promoting tubularity or fragmentation depending on cellular conditions and interacts with calcineurin and PINK1 under basal conditions, while its depletion in C. elegans leads to mitochondrial fission, lifespan extension, and enhanced survival under oxidative stress. [Read the Full Post]

Nanodroplet-enhanced sonodynamic therapy potentiates immune checkpoint blockade for systemic suppression of triple-negative breast cancer

208 views | Feb 25 2023

The combination of STING activation, hypoxia relief, and sonodynamic therapy with anti-PD-L1 therapy using an O2-filled nanodroplet shows strong efficacy in suppressing triple-negative breast cancer growth and improving therapeutic outcome by promoting mature DCs, inducing immunogenic cell death, and enhancing tumor infiltration of CTLs. [Read the Full Post]