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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

RON

Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype

101 views | Jan 11 2024

This study's establishment of a physiologically relevant in vitro system for TAM polarization unveils BMS-794833 as a potent inhibitor, independent of primary targets but reliant on multiple signaling pathways, offering a promising strategy to reprogram TAMs and suppress cancer growth. [Read the Full Post]

Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models

126 views | Aug 20 2023

SCC244, a novel and highly selective inhibitor of c-Met kinase, demonstrated potent antitumor activity in preclinical studies, inhibiting c-Met signaling and suppressing neoplastic phenotypes in tumor and endothelial cells, suggesting its potential as a therapeutic agent for tumors with c-Met pathway alterations. [Read the Full Post]

SS18-SSX drives CREB activation in synovial sarcoma

85 views | Jan 24 2023

Magdalene Cyra et al. showed that CREB was phosphorylated and activated in SySa, accompanied by downstream target expression. [Read the Full Post]

Assessment of the Immune Response to Tumor Cell Apoptosis and Efferocytosis

136 views | Dec 03 2022

Thomas A Werfel et al. described a model that enabled in vivo studies of tumor immunology in the aftermath of cytotoxic therapy with an emphasis on the impact of efferocytosis. [Read the Full Post]

Radiotherapy alters expression of molecular targets in prostate cancer in a fractionation- and time-dependent manner

328 views | Mar 09 2022

Iris Eke et al. found that understanding the molecular short- and long-term changes after irradiation could aid in optimizing the efficacy of multimodal radiation oncology in combination with post-irradiation molecularly-targeted drug treatment and improving the outcome of prostate cancer patients. [Read the Full Post]

The MSP-RON pathway regulates liver fibrosis through transforming growth factor beta-dependent epithelial-mesenchymal transition

292 views | Jan 09 2022

Tianhao Weng et al. revealed that MSP was an important biomarker in liver cirrhosis progression and could be used to prognose patients. [Read the Full Post]

Depletion of insulin-like growth factor 1 receptor increases radiosensitivity in colorectal cancer

654 views | Mar 21 2021

Yi Li et al. supported the notion that the radiosensitivity of radiation-resistant colorectal cancer cells could be enhanced by directly targeting IGF1R expression or activity. [Read the Full Post]