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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

5-HT Receptor

Altered brain serotonin 5-HT1A receptor expression and function in juvenile Fmr1 knockout mice

59 views | Jan 09 2024

The study's findings on 5-HT1A receptor expression and responsiveness to agonists in juvenile Fmr1 knockout mice suggest a promising therapeutic potential of 5-HT1AR agonists for managing auditory hypersensitivity and seizures in young individuals with Fragile X syndrome. [Read the Full Post]

Active natural compounds perturb the melanoma risk-gene network

179 views | Jan 07 2024

The study ingeniously employs network modeling of melanoma-associated genes, revealing crucial pathways and potential therapeutic targets while showcasing the predictive potential of this model in evaluating the efficacy of anti-melanoma phytochemicals. [Read the Full Post]

Dual action of serotonin on local excitatory and inhibitory neural circuits regulating the corticotropin-releasing factor neurons in the paraventricular nucleus of the hypothalamus

59 views | Dec 16 2023

Serotonin modulates corticotropin-releasing factor (CRF) neurons in the paraventricular nucleus of the hypothalamus by upregulating glutamatergic interneurons via 5-HT7 receptors and downregulating GABAergic interneurons via 5-HT2C receptors, as demonstrated in an electrophysiological study using the CRF-modified yellow fluorescent protein (Venus) ΔNeo mouse model. [Read the Full Post]

Nuciferine protects against lipopolysaccharide-induced endometritis via inhibiting ferroptosis and modulating AMPKα/mTOR/HIF-1α signaling axis

90 views | Nov 16 2023

Nuciferine (NF) demonstrates protective effects against lipopolysaccharide (LPS)-induced endometritis in mice by modulating multiple pathways, including MyD88/NF-κB, MAPK, ferroptosis, and the AMPKα/mTOR/HIF1α signaling axis, while also exerting direct anti-inflammatory effects in endometrial epithelial cells through the inhibition of the NF-κB signaling pathway. [Read the Full Post]

[Therapeutic drug monitoring of antipsychotic drugs in routine psychiatric practice]

151 views | Oct 01 2023

This study examined the relationship between daily doses of antipsychotic drugs, their serum concentrations, and patient characteristics in the treatment of schizophrenia, highlighting the importance of therapeutic drug monitoring and individual patient factors on drug exposure. [Read the Full Post]

Antidepressant efficacy of cariprazine in bipolar disorder and the role of its pharmacodynamic properties: A hypothesis based on data

124 views | May 04 2023

The study investigated whether the pharmacodynamic properties of cariprazine fit into a previously developed model for the treatment of bipolar depression, which was based on a combination of clinical and preclinical data, and found that its properties fit well with the proposed model, but further clarification is needed regarding its norepinephrine reuptake inhibition. [Read the Full Post]

Can pharmaceutical pollution alter the spread of infectious disease? A case study using fluoxetine

138 views | Feb 17 2023

Fluoxetine exposure affects the severity of a bacterial infection in water fleas in a non-monotonic manner, but the effect varies with both the infection outcome measured and the genotype of the pathogen, leading to complex genotype-by-environment interactions in its influence on disease dynamics. [Read the Full Post]

Antidepressant drugs use and epilepsy risk: A nationwide nested case-control study

107 views | Feb 16 2023

A case-control study in Taiwan found a higher risk of epilepsy among patients exposed to antidepressants, particularly with longer-term use, and showed a higher risk for escitalopram, venlafaxine, mirtazapine, paroxetine, and fluoxetine, but not for sertraline, fluvoxamine, citalopram, duloxetine, milnacipran, and bupropion. [Read the Full Post]

5-HT4 receptors facilitate cholinergic neurotransmission throughout the murine gastrointestinal tract

1089 views | Dec 11 2018

Pauwelyn V et al. showed that in the murine gastrointestinal tract, activation of 5-HT4 receptors with prucalopride enhances cholinergic contractions, illustrating facilitation of myenteric cholinergic neurotransmission. The degree of enhancement with prucalopride is of similar magnitude as previously reported in other species, but the effective concentrations are lower than those needed in the gastrointestinal tract of other species. [Read the Full Post]

Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT1A Receptor

984 views | Nov 30 2018

Mi G et al. suggested that l-THBr may produce potent anxiolytic-like effects mainly through serotonin receptors. [Read the Full Post]