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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

p97

Inhibitors of the ATPase p97/VCP: From basic research to clinical applications

0 views | Jan 22 2024

In this review, the focus lies on the development and evolution of various p97 inhibitors, notably ATPase inhibitors like CB-5083 and CB-5339, which have exhibited potent anti-tumor activity across diverse models, offering a promising approach for cancer therapy by targeting protein degradation pathways. [Read the Full Post]

Inhibitors of the ATPase p97/VCP: From basic research to clinical applications

131 views | Jul 17 2023

The development of p97 inhibitors as UPS-targeting cancer therapies represents a promising approach for addressing protein homeostasis deficiencies underlying various cancers and neurodegenerative diseases. [Read the Full Post]

Targeting endoplasmic reticulum associated degradation pathway combined with radiotherapy enhances the immunogenicity of esophageal cancer cells

43 views | Jun 01 2023

The study found that inhibiting ERAD pathways combined with moderate dose radiation therapy can enhance the immunogenicity of esophageal cancer cells, leading to an improved antitumor immune response and favorable clinical outcomes. [Read the Full Post]

The p97 Inhibitor UPCDC-30245 Blocks Endo-Lysosomal Degradation

240 views | Mar 13 2022

Feng Wang et al. found UPCDC-30245 exhibited antiviral effects against coronavirus by blocking viral entry. [Read the Full Post]

A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells

440 views | Mar 26 2021

Gang Zhang et al. identified and characterized PPA as a selective covalent p97 inhibitor, which would allow future exploration to improve the potency of p97 inhibitors with different mechanisms of action. [Read the Full Post]

Bifunctional alkylating agent-mediated MGMT-DNA cross-linking and its proteolytic cleavage in 16HBE cells

0 views | Jun 24 2017

Cheng J et al. demonstrated that MGMT might turn into a DNA damage promoter by forming DPC when exposed to HN2. Proteolysis, especially DVC1, plays a crucial role in mDPC repair. [Read the Full Post]