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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

TRP Channel

Puerarin ameliorates myocardial remodeling of spontaneously hypertensive rats through inhibiting TRPC6-CaN-NFATc3 pathway

70 views | Dec 25 2023

Puerarin administration in spontaneously hypertensive rats demonstrated significant improvements in cardiac function and myocardial structure, potentially mediated by its inhibition of the TRPC6-CaN-NFATc3 pathway, suggesting promise for Puerarin as a therapeutic intervention in hypertensive myocardial remodeling. [Read the Full Post]

Pharmacological Modulation of the Ca2+/cAMP/Adenosine Signaling in Cardiac Cells as a New Cardioprotective Strategy to Reduce Severe Arrhythmias in Myocardial Infarction

105 views | Dec 18 2023

The study demonstrates that blocking L-type Ca2+ channels attenuates cardiac arrhythmias induced by acute myocardial infarction, implicating the Ca2+/cAMP/adenosine signaling pathway as a promising therapeutic target to reduce severe and fatal arrhythmias in humans. [Read the Full Post]

Simulated microgravity-induced oxidative stress and loss of osteogenic potential of osteoblasts can be prevented by protection of primary cilia

72 views | Dec 09 2023

Microgravity-induced shortening of primary cilia triggers overexpression and hyperactivity of TRPV4 channels, leading to intracellular Ca2+ overload, oxidative stress, and loss of osteogenic potential in osteoblasts, a process preventable by protecting primary cilia. [Read the Full Post]

Revisiting matrix hydrogel composed of gelatin and hyaluronic acid and its application in cartilage regeneration

81 views | Nov 25 2023

The biomacromolecule-based bioadhesive matrix hydrogel, composed of methacrylate gelatin and modified hyaluronic acid, demonstrates promising potential for cartilage repair by promoting tissue integration, supporting chondrogenesis of stem cells, and enhancing articular cartilage regeneration in knee osteoarthritis. [Read the Full Post]

Involvement of a flavoprotein, acetohydroxyacid synthase, in growth and riboflavin production in riboflavin-overproducing Ashbya gossypii mutant

187 views | Aug 16 2023

This study demonstrates that branched-chain amino acids, particularly through the regulation of acetohydroxyacid synthase, play a crucial role in enhancing riboflavin production in the Ashbya gossypii mutant strain, offering a novel approach for optimizing riboflavin production in this organism. [Read the Full Post]

Melatonin promotes orofacial antinociception in adult zebrafish by modulating TRP channels

133 views | Jul 20 2023

Melatonin demonstrated an orofacial antinociceptive effect in adult zebrafish, which was associated with the modulation of TRP channels, particularly TRPV1. [Read the Full Post]

Luteolin-7-O-rutinoside Protects RIN-5F Cells from High-Glucose-Induced Toxicity, Improves Glucose Homeostasis in L6 Myotubes, and Prevents Onset of Type 2 Diabetes

133 views | Mar 24 2023

Lut-7-O-rutin has been found to have a protective effect on high-glucose-induced toxicity to RIN-5F cells and improve insulin secretion and glucose uptake through various molecular mechanisms. [Read the Full Post]

Loss of TRPV4 Cation Channel Inhibition of Macrophage Infiltration and Neovascularization in a Mouse Cornea

129 views | Mar 12 2023

This study shows that TRPV4 plays a role in injury-induced neovascularization in the corneal stroma and may be a potential therapeutic target to prevent unfavorable neovascularization post-injury. [Read the Full Post]