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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

HIV Protease

Semi-quantification and Potency Verification of the HIV Protease Inhibitor Based on the Matrix-Capsid Protein Immobilized Nickel (II)/NTA-Tol/Graphene Oxide/SPCE Electrochemical Biosensor

95 views | Sep 15 2023

The study proposes a low-cost electrochemical biosensor platform for the semi-quantification and verification of HIV protease inhibitors, offering a potential solution to expedite the discovery and development of new HIV drugs. [Read the Full Post]

Characterization of a Novel Milk-Clotting Aspartic Protease from Penicillium sp. and Structural Explanation for its High Milk-Clotting Index

138 views | Jun 06 2023

PsMCE is a novel milk-clotting enzyme with specific hydrolysis activity on κ-casein proteins and potential applications in cheese making due to its thermolability and high milk-clotting index value. [Read the Full Post]

Mutiple myeloma resistant to melphalan (NSC-8806) treated with cyclophosphamide (NSC-26271), prednisone (NSC-10023), and chloroquine (NSC-187208)

114 views | May 17 2023

This prospective randomized study compared the effectiveness of two therapeutic regimens in 41 patients with multiple myeloma resistant to melphalan, with no significant differences in response or toxicity observed between the groups, despite the addition of chloroquine to one regimen. [Read the Full Post]

A myeloid leukemia factor homolog is involved in tolerance to stresses and stress-induced protein metabolism in Giardia lamblia

112 views | May 16 2023

This study investigated the role of MLF vesicles in G. lamblia and found that they share similar stress-induced characteristics with autophagy compartments and are important for survival in stress conditions. [Read the Full Post]

Targeting chromosome 12q amplification in relapsed glioblastoma: the use of computational biological modeling to identify effective therapy-a case report

105 views | Apr 24 2023

The case report demonstrates the utility of biosimulation in identifying effective treatment options based on comprehensive genomic abnormalities and highlights a promising treatment combination for GBM and potentially other cancers harboring chromosome 12q amplification. [Read the Full Post]

The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation

104 views | Apr 24 2023

The research shows that the transcription factor Nrf3 regulates macropinocytosis and autophagy to coordinate melanogenesis, and has potential therapeutic implications for hyperpigmentation disorders and as an anti-melanogenic target in HIV-1 infected individuals taking nelfinavir. [Read the Full Post]

In-vitro dynamic dissolution/bioconversion/permeation of fosamprenavir using a novel tool with an artificial biomimetic permeation barrier and microdialysis-sampling

77 views | Mar 02 2023

A novel cell-free in vitro setup was developed and tested to evaluate the dynamic dissolution, bio-conversion, and permeation of fosamprenavir, showing promising results for gaining a deeper understanding of the bioconversion and permeation of phosphate-ester prodrugs. [Read the Full Post]

Understanding the impact of halogen functional group (Br, Cl, F, OH) in amprenavir ligand of the HIV protease

134 views | Mar 01 2023

Study provides valuable insights into the structure-activity relationship of protein-ligand interactions in HIV/AIDS research and highlights the importance of halogen and hydrogen bond interactions in the development of new antiviral drugs. [Read the Full Post]

Understanding drug resistance patterns across different classes of antiretrovirals used in HIV-1-infected treatment-Naïve and experienced patients in Mumbai, India

88 views | Feb 28 2023

The study found that treatment-experienced patients had higher incidence of high-level resistance to antiretroviral drugs compared to treatment-naive patients, with a positive correlation observed for within class resistance across antiretrovirals, and highlights the importance of genotypic drug resistance testing before starting treatment. [Read the Full Post]

HIV-Tat Exacerbates the Actions of Atazanavir, Efavirenz, and Ritonavir on Cardiac Ryanodine Receptor (RyR2)

116 views | Feb 21 2023

The study shows that HIV-Tat, ATV, EFV, and RTV can bind to and modulate the activity of the type 2 ryanodine receptor (RyR2) in the heart and that HIV-Tat can exacerbate the actions of ATV, EFV, and RTV on RyR2, potentially increasing the risk of cardiac arrhythmias and sudden cardiac death. [Read the Full Post]