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PI3K/Akt/mTOR
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Methylation
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Immunology & Inflammation
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Protein Tyrosine Kinase
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Angiogenesis
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Apoptosis
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- OXPHOS
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Autophagy
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ER stress & UPR
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JAK/STAT
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MAPK
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Cytoskeletal Signaling
- Akt
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- Actin
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Cell Cycle
- CDK
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- PD-1/PD-L1
- Ras
- Aurora Kinase
- HSP (HSP90)
- Kinesin
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- Microtubule Associated
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- Myc
- Serine/threonin kinase
- PAK
- Rho
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- DYRK
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- PERK
- Mad2
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- AP-1
- BMI-1
- DOCK
- p21
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TGF-beta/Smad
- TGF-beta/Smad
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- PKC
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DNA Damage/DNA Repair
- HDAC
- ATM/ATR
- PARP
- DNA/RNA Synthesis
- PPAR
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- Topoisomerase
- DNA-PK
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- MTH1
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- G-quadruplex
- RNR
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- Nucleoside Analog/Antimetabolite
- LIM kinase
- RAD51
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- BMI-1
- Pax
- FENs
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Stem Cells & Wnt
- GSK-3
- JAK
- STAT
- TGF-beta/Smad
- Wnt/beta-catenin
- ROCK
- Hedgehog/Smoothened
- PKA
- Stemness kinase
- KLF
- OCT
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- ERK
- SFRP
- Fascin
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- Notch
- Secretase
Hippo
- LATS
- TEAD
- MAP4K
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- YAP
Ubiquitin
- Proteasome
- DUB
- p97
- E1 Activating
- SUMO
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- E3 Ligase
Neuronal Signaling
- Calcium Channel
- Beta Amyloid
- 5-HT Receptor
- COX
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GABA Receptor
- P-gp
- P2 Receptor
- Cannabinoid Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- MAO
- FAAH
- BACE
- Trk receptor
- GlyT
- NMDAR
- CaMK
- Notch
- Imidazoline Receptor
- Sigma Receptor
- NPY receptor
- Serotonin Transporter
- CCK receptor
- Neurotensin Receptor
- COMT
- Melanocortin Receptor
- Adenosine Deaminase
- TRP Channel
- Adenosine Kinase
- BChE
- EAAT
- Neurokinin Receptor
NF-κB
- HDAC
- NF-κB
- IκB/IKK
- MALT
- Nrf2
- ROS
- NOD
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- AP-1
GPCR & G Protein
- Ras
- 5-HT Receptor
- CCR
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GPR
- P2 Receptor
- Cannabinoid Receptor
- Endothelin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- SGLT
- LPA Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- PAFR
- PKA
- Adenosine Receptor
- Vasopressin Receptor
- cAMP
- CXCR
- TAAR
- CaSR
- Glucagon Receptor
- LTR
- Parathyroid Hormone Receptor
- NPY receptor
- DOCK
- AdipoR
- GPCR19
- Guanylate Cyclase
- GHSR
- CCK receptor
- FPR
- GRK
- Leukotriene
- Prostaglandin Receptor
- PKD
- TSH Receptor
- Neurokinin Receptor
- GNRH Receptor
- CRFR
- PKG
- Bradykinin Receptor
- Angiotensin Receptor
- Bombesin Receptor
- Imidazoline Receptor
- Neurotensin Receptor
- RGS
- Melanocortin Receptor
- Sigma Receptor
- Taste Receptor
- PAR
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
- Glucocorticoid Receptor
- THR
- ACE
- SSTR
- GHSR
- CCK receptor
- PGES
- TSH Receptor
- GNRH Receptor
- PGDS
- Mineralocorticoid Receptor
Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
- AChR
- GABA Receptor
- P-gp
- Proton Pump
- CFTR
- P2 Receptor
- SGLT
- GLUT
- GlyT
- NMDAR
- OCT
- CRM1
- MCT
- Amino acid transporter
- OAT
- Mechanosensitive Channel
- BCRP
- NKCC
- NCX
- TRP Channel
- OATP
- VRAC
- Aquaporin
- EAAT
- VDAC
- MTP
- VMAT
- GlyR
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
- Carbonic Anhydrase
- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- Serine/threonin kinase
- CETP
- IDO/TDO
- phosphatase
- GLUT
- HMG-CoA Reductase
- Vitamin
- PKM
- Lipoxygenase
- FOX
- Lipase
- Fatty Acid Synthase
- LDL
- NAMPT
- Decarboxylase
- Casein Kinase
- Thioredoxin
- Retinoid Receptor
- Transferase
- FXR
- Neprilysin
- PP2A
- FTO
- RUNX
- SREBP
- AdipoR
- PAD
- CPT
- SCD
- CAR
- AP-1
- LDH
- Carbohydrate Metabolism
- γGCS
- SSTR
- PAI-1
- FTase
- SOD
- ATP-citrate lyase
- FAO
- SGK
- GOT
- 3-MST
- GTPCH
- glucocerebrosidase
- FABP
- Serine hydrolase
- Epoxide Hydrolase
- ACSS2
- ROR
- Catalase
- THR
- PDHK
- Glucosylceramide Synthase
- ACE
- Thioredoxin Reductase
- PGC-1α
- PARG
- Xanthine Oxidase
- Mannosidase
- Leukotriene
- Adenosine Deaminase
- Aldose Reductase
- CPSase
- Acetyl-CoA carboxylase
- Adenosine Kinase
- OXPHOS
- Glutathione
- PCSK9
- Mitochondrial Metabolism
- Peroxidases
- SHIP
- PGDS
- Mitochondrial pyruvate carrier
- PREP
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- MALT
- Glutaminase
- Tyrosinase
- Serine Protease
- Cysteine Protease
- PAD
- PCSK9
- Secretase
- Cathepsin B
- PGDS
- Neprilysin
- SGK
- PREP
- GOT
- 3C-Like Protease
Microbiology
- HCV Protease
- Integrase
- Reverse Transcriptase
- HIV Protease
- Anti-infection
- Fungal
- CMV
- Neuraminidase
- Parasite
- Antiviral
- Thioredoxin Reductase
- Bacterial
- β-lactamase
- Antibiotics
- 3C-Like Protease
- Enterovirus
- COVID-19
- Influenza Virus
- Ribosomal Peptidyl Transferase
- SARS-CoV
- RSV
- HPV
- HSV
- HCV
- HBV
- HIV
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

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The study demonstrates that the TLR4 inflammatory cascade disrupts vascular integrity by downregulating Dock1 and Elmo1 expression, highlighting Dock1 as a critical target in TLR4-mediated inflammatory lung injury and emphasizing its essential role in maintaining endothelial cell junctional integrity. [Read the Full Post]

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A genome-wide association study in a Japanese population identified a specific genetic variant (rs60200309-A) near the DOCK2 gene on chromosome 5, linked to decreased DOCK2 expression in immune cells, revealing its crucial role in the host immune response to SARS-CoV-2 infection and suggesting its potential as a biomarker and therapeutic target for severe COVID-19. [Read the Full Post]