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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

[The Effect of KRAS on Proliferation and Apoptosis of T-ALL Cell Lines]

42 views | Aug 24 2022

Zi-Yang Liu et al. thought that the KRAS protein was vital for the progression of the T-ALL cells in vitro, it was a potential therapeutic target for T-ALL patients. [Read the Full Post]

Phase I trial of ribociclib with platinum chemotherapy in recurrent ovarian cancer

46 views | Aug 23 2022

Lan G Coffman et al. demonstrated the combination of ribociclib with chemotherapy in ovarian cancer was feasible and safe. [Read the Full Post]

Inhibition of EZH2 suppresses peritoneal angiogenesis by targeting a VEGFR2/ERK1/2/HIF-1α-dependent signaling pathway

37 views | Aug 23 2022

Yingfeng Shi et al. suggested that EZH2 might be a novel target for preventing peritoneal angiogenesis in PD patients. [Read the Full Post]

Alpha1B-adreneroceptor is involved in norepinephrine-induced pulmonary artery smooth muscle cell proliferation via p38 signaling

84 views | Aug 22 2022

Xiaolin Xiao et al. suggested that α1B-AR was involved in NE-induced PASMCs proliferation via p38 signaling pathway, which might be downstream of α1B-AR. [Read the Full Post]

Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL

63 views | Aug 22 2022

Yinan Yuan et al. found that inhibiting the protein-protein interactions between DOT1L and MLL fusion proteins was a potentially effective strategy for the treatment of MLL rearranged leukemias. [Read the Full Post]

In vitro and in vivo evaluation of kinase and protease inhibitors against Trypanosoma evansi

91 views | Aug 21 2022

Wangchuk Dorjee Bhutia et al. showed that kinase inhibitors had higher potential to explore therapeutic molecules against surra organism. [Read the Full Post]

Discovery of Novel GMPS Inhibitors of Candidatus Liberibacter Asiaticus by Structure Based Design and Enzyme Kinetic

0 views | Aug 21 2022

Jing Nan et al. suggested that folic acid and AZD1152 could be considered as promising candidates for the development of CLas agents. [Read the Full Post]

Bcl-x L as prognostic marker and potential therapeutic target in cholangiocarcinoma

48 views | Aug 20 2022

P Hoffmeister et al. found that Bcl-xL as a key protein in cell death resistance of CCA and may pave the way for clinical application. [Read the Full Post]

FGF2 positively regulates osteoclastogenesis via activating the ERK-CREB pathway

106 views | Aug 20 2022

Xin Wen et al. established the importance of FGF2 in bone homeostasis, hinting the potential use of FGF2/ERK/CREB specific inhibitors to fight against bone-related disorders, such as osteoporosis. [Read the Full Post]

Expression, purification, and kinetic characterization of the human strep-IDO1

92 views | Aug 19 2022

Dilizhatai Saimi et al. thought that purified human strep-IDO1 using the protocol described in the study could be used for further biochemical and structural analyses, which might facilitate functional research and further drug screening study on IDO1. [Read the Full Post]

IDO1 Inhibition Reduces Immune Cell Exclusion Through Inducing Cell Migration While PD-1 Blockage Increases IL-6 and -8 Secretion From T Cells in Head and Neck Cancer

82 views | Aug 19 2022

Meri Sieviläinen et al. revealed the subpopulation of lymphocytes responsible for the increases in specific serum cytokines after ICI treatment. [Read the Full Post]

Activation of SIRT1 Alleviates Ferroptosis in the Early Brain Injury after Subarachnoid Hemorrhage

55 views | Aug 18 2022

Bin Yuan et al. found that ferroptosis could be a potential therapeutic target for SAH, and SIRT1 activation was a promising method to inhibit ferroptosis. [Read the Full Post]

Salidroside Ameliorates Ultraviolet-Induced Keratinocyte Injury by Inducing SIRT1-Dependent Autophagy

65 views | Aug 18 2022

Jin Ke et al. thought that SAL suppressed UVB-induced injury and autophagy by enhancing SIRT1 expression. [Read the Full Post]

Atezolizumab, vemurafenib, and cobimetinib in patients with melanoma with CNS metastases (TRICOTEL): a multicentre, open-label, single-arm, phase 2 study

131 views | Aug 17 2022

Reinhard Dummer et al. evaluated atezolizumab in combination with cobimetinib or vemurafenib plus cobimetinib in patients with melanoma with CNS metastases. [Read the Full Post]

Phase 1 study to evaluate the effects of rifampin on pharmacokinetics of pevonedistat, a NEDD8-activating enzyme inhibitor in patients with advanced solid tumors

61 views | Aug 17 2022

Xiaofei Zhou et al, supported the recommendation that no pevonedistat dose adjustment was needed for patients receiving concomitant CYP3A inducers. [Read the Full Post]

Small Molecule Inhibitors of MERTK and FLT3 Induce Cell Cycle Arrest in Human CD8 + T Cells

80 views | Aug 15 2022

Richard M Powell et al. found that caution was needed when using potent RTKIs in the context of antitumor immune responses. [Read the Full Post]

Human osteoprogenitor cells obtained from traumatic heterotopic ossification samples showed enhanced osteogenic differentiation potential and ERK/Hedgehog signaling than that from normal bone

108 views | Aug 15 2022

Tongtong Zhang et al. found that the activation of ERK and Hedgehog signaling pathway jointly enhanced the osteogenic potential of HO-ops to induce the formation of traumatic HO. [Read the Full Post]

Epiprofin Transcriptional Activation Promotes Ameloblast Induction From Mouse Induced Pluripotent Stem Cells via the BMP-Smad Signaling Axis

51 views | Aug 14 2022

Xinchao Miaosuggested that Epfn was a promising target for inducing the differentiation of ameloblasts, which could be used in enamel and tooth regeneration. [Read the Full Post]

A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML

86 views | Aug 14 2022

Baohuan Cai et al. demonstrated a novel model for transformation of hematopoietic stem cells by chimeric FGFR1 kinases with the combined effects of direct protein activation by the full-length kinases and transcriptional regulation by the truncated nuclear tnFGFR1 derivative. [Read the Full Post]

Evaluation of the Efficacy of Saracatinib-Loaded Nanoparticles in Lymphatic Metastases of HNSCC with the Aid of Bioluminescence Imaging

84 views | Aug 13 2022

Liwei Lang et al. showed great potential to evaluate treatments on metastatic diseases with the aid of bioluminescent technology. [Read the Full Post]