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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Kong, X., Y. Shen, et al. (2011). "Emerging roles of DNA-PK besides DNA repair." Cell Signal 23(8): 1273-1280.

5193 views | Aug 19 2011

This article reviews the role of DNA-PK from two aspects. It not only introduces the regulation of DNA-PK activity and the roles of DNA-PK in non-homologous end-joining (NHEJ) repair and homologous recombinant (HR) repair, but also introduces the involvement of DNA-PK in the inflammatory response, in metabolic gene regulation, and in the homeostasis of cell proliferation as well. [Read the Full Post]

Brinkmann, V. (2007). "Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology." Pharmacol Ther 115(1): 84-105.

3625 views | Jul 22 2011

This article reviews S1P receptor subtypes and associated signaling pathways. The relationship between S1P receptors and different diseases is proved in the article. [Read the Full Post]

Huang, H., A. Bhat, et al. (2010). "Targeting the ANGPT-TIE2 pathway in malignancy." Nat Rev Cancer 10(8): 575-585.

3702 views | Jul 20 2011

This article which is published in Nature review cancer introduce the role of Tie2 in signal transduction such as angiogenesis. It also concludes the inhibitors of Tie2 kinase in cancer therapeutics. [Read the Full Post]

Chiarle, R., C. Voena, et al. (2008). "The anaplastic lymphoma kinase in the pathogenesis of cancer." Nat Rev Cancer 8(1): 11-23.

4783 views | Jul 19 2011

This review which was published in Nature Reviews Cancer concludes the pathways which ALK is involved in and targets that ALK is related to. The content also includes ALK as a therapeutic target in cancer. [Read the Full Post]

Rosse, C., M. Linch, et al. (2010). "PKC and the control of localized signal dynamics." Nat Rev Mol Cell Biol 11(2): 103-112.

5053 views | Jul 19 2011

This review which was published in Nature review summary the role of PKC in different pathways and show the importance of PKCs in controlling spatial resolution in signaling processes using the MET and STAT3 example. [Read the Full Post]

Mumenthaler, S. M., P. Y. Ng, et al. (2009). "Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes." Mol Cancer Ther 8(10): 2882-2893.

5205 views | Jul 17 2011

These findings support the idea that inhibiting Pim kinases, in combination with a chemotherapeutic agent, could play an important role in prostate cancer treatment by targeting the clinical problem of chemoresistance. [Read the Full Post]

Wong, K. K., J. A. Engelman, et al. (2010). "Targeting the PI3K signaling pathway in cancer." Curr Opin Genet Dev 20(1): 87-90.

2633 views | Jul 16 2011

This is a short review which gives a brief introduction of PI3K and PI3K inhibitors related to cancer research. [Read the Full Post]

Dietrich, J., V. Gokhale, et al. (2010). "Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors." Bioorg Med Chem 18(1): 292-304.

2928 views | Jul 15 2011

An article about drug discovery of b-raf inhibitor design and molecular modeling. [Read the Full Post]

Munoz, L. and A. J. Ammit (2010). "Targeting p38 MAPK pathway for the treatment of Alzheimer

2894 views | Jul 14 2011

This is an introduction of the relationship between p38 MAPK and Alzheimer's disease because p38 MAPK plays an important role in Alzheimer's disease. It also list the p38 MAPK inhibitors Alzheimer's disease patients could benefit from. [Read the Full Post]

Yin, L., O. C. Velazquez, et al. (2010). "Notch signaling: emerging molecular targets for cancer therapy." Biochem Pharmacol 80(5): 690-701.

5737 views | Jul 13 2011

This article is a review which give a presentation of Notch signal pathway and how the researchers target Notch signal pathway for a cancer therapy. [Read the Full Post]

Wong, K. K. (2009). "Recent developments in anti-cancer agents targeting the Ras/Raf/ MEK/ERK pathway." Recent Pat Anticancer Drug Discov 4(1): 28-35.

2714 views | Jul 12 2011

Give an introduction of inhibitors targeting the Ras/Raf/ MEK/ERK pathway. This article summaries the current and future development of anti-cancer drugs or inhibitors of Ras/Raf/ MEK/ERK pathway and the difference between those drugs or inhibitors. [Read the Full Post]

Eldar-Finkelman, H., A. Licht-Murava, et al. (2010). "Substrate competitive GSK-3 inhibitors - strategy and implications." Biochim Biophys Acta 1804(3): 598-603.

4495 views | Jul 11 2011

A short article introduces the substrates and inhibitors of GSK-3 and the relationship between substrates of GSK-3 and GSK-3. [Read the Full Post]

Chipuk, J. E., T. Moldoveanu, et al. (2010). "The BCL-2 family reunion." Mol Cell 37(3): 299-310.

3197 views | Jul 9 2011

The newest review which give a overview of the BCL-2 family proteins including detail data of bcl-2 proteins, the signal transduction related to the bcl-2 and Pharmacological Regulation of the Bcl-2 Proteins [Read the Full Post]

Chin, Y. R. and A. Toker (2009). "Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer." Cell Signal 21(4): 470-476.

3504 views | Jun 23 2011

This article gives an introduction of akt signal pathway in cell motility, invasion and the tumor stroma in cancer. We can learn this overview of relationship between Akt and cancer. [Read the Full Post]

Chi V. Dang (2008)."The interplay between MYC and HIF in cancer" Nat Rev Cancer 8(1): 51-56

4637 views | Jun 14 2011

This review concludes the interaction among MYC, HIF and cancer. It also concludes the cancer cellular responses in low oxygen levels. [Read the Full Post]

Takayuki Ikezoe (2008). “Aurora kinases as an anti-cancer target” Cancer Letters 262(2-3): 1–9

4510 views | Jun 13 2011

This review highlights the function of Aurora kinases in the regulation of mitosis and presents the rationale for these kinases as an anti-cancer target. I also review recently developed inhibitors of Aurora kinases. [Read the Full Post]

Padera, T. P. and R. K. Jain (2008). "VEGFR3: a new target for antiangiogenesis therapy?" Dev Cell 15(2): 178-179.

2596 views | Jun 13 2011

This review is about VEGFR-3,which are related to Notch pathway. It concludes a article which is published in Nature about VEGFR-3. [Read the Full Post]

Nitiss, J. L. (2009). "Targeting DNA topoisomerase II in cancer chemotherapy." Nat Rev Cancer 9(5): 338-350.

3298 views | Jun 12 2011

The molecular tools that have allowed an understanding of the biological functions of TOP2 are also being applied to understanding the details of drug action. These studies promise refined targeting of TOP2 as an effective anticancer strategy. [Read the Full Post]

Altieri, D. C. (2008). "Survivin, cancer networks and pathway-directed drug discovery." Nat Rev Cancer 8(1): 61-70.

3937 views | Jun 11 2011

A fantastic review about survivin which was published in NATURE REVIEW CANCER. It concludes nearly all the important pathways which survivin is involved in. We can find wonderful pictures of pathways in this review [Read the Full Post]

Rosen, H., P. J. Gonzalez-Cabrera, et al. (2009). "Sphingosine 1-phosphate receptor signaling." Annu Rev Biochem 78: 743-768.

3587 views | Jun 10 2011

This review gives us the detail information about S1P receptors from different aspects including subtypes and Genetic Relationships, coupling Promiscuity and Its Consequences, design Features of the S1P Ligand System, S1P Receptor Signaling in Health and Disease and son on. [Read the Full Post]