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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Advances in lung adenocarcinoma: A novel perspective on prognoses and immune responses of CENPO as an oncogenic superenhancer

37 views | Nov 05 2023

This study reveals that the overexpression of Centromere protein O (CENPO) in lung adenocarcinoma is associated with a poor prognosis, and its involvement in immunosuppression and drug resistance highlights its potential as a prognostic biomarker and therapeutic target. [Read the Full Post]

Nobiletin Mitigates D-Galactose-Induced Memory Impairment via Improving Hippocampal Neurogenesis in Mice

59 views | Nov 05 2023

The study found that administration of nobiletin (NOB) attenuated memory impairment, restored hippocampal neurogenesis, reduced neuroinflammation, and improved brain function in D-galactose-induced aging mice, suggesting NOB as a potential neurogenesis enhancer for mitigating brain aging. [Read the Full Post]

Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target

73 views | Nov 05 2023

This study suggests that targeting BMI1, an epigenetic regulator, may offer a potential therapeutic strategy for alveolar rhabdomyosarcoma (ARMS) by inhibiting cell growth, promoting apoptosis, and activating the Hippo pathway. [Read the Full Post]

GRP78 Inhibitor YUM70 Suppresses SARS-CoV-2 Viral Entry, Spike Protein Production and Ameliorates Lung Damage

96 views | Nov 04 2023

The study demonstrated that the small molecule inhibitor YUM70, which targets the GRP78 protein, effectively blocked SARS-CoV-2 viral entry and infection in vitro and in vivo, suggesting its potential as a promising therapeutic approach against COVID-19 and its variants. [Read the Full Post]

The role of serotonin inhibition within the treatment of carcinoid syndrome

45 views | Nov 04 2023

Carcinoid syndrome, characterized by symptoms such as diarrhea, flushing, and abdominal pain, is primarily managed through the use of somatostatin analogues, surgical resection for potential cure, and other therapies such as loco-regional interventional radiological procedures, peptide receptor radionuclide therapy, and targeted medications. [Read the Full Post]

Silencing of RhoC induces macrophage M1 polarization to inhibit migration and invasion in colon cancer via regulating the PTEN/FOXO1 pathway

50 views | Nov 04 2023

This study shows that silencing RhoC in colon cancer cells reduces invasion, migration, and tumor growth by suppressing M2 macrophage polarization and modulating the PTEN/FOXO1 pathway. [Read the Full Post]

Regulation of pericyte metabolic reprogramming restricts the AKI to CKD transition

44 views | Nov 04 2023

Metabolic reprogramming, characterized by decreased fatty acid oxidation and increased glycolysis, plays a critical role in pericyte-myofibroblast transition and targeting pericyte metabolism may prevent the progression of acute kidney injury to chronic kidney disease. [Read the Full Post]

Statins protect mice from high-decibel noise-induced hearing loss

49 views | Nov 04 2023

The study found that direct delivery of fluvastatin to the cochlea and oral administration of lovastatin showed potential protective effects against noise-induced hearing loss in CBA/CaJ mice, as evidenced by reduced threshold shifts in auditory brainstem responses. [Read the Full Post]

Novel Glutamine Antagonist JHU395 Suppresses MYC-Driven Medulloblastoma Growth and Induces Apoptosis

43 views | Nov 03 2023

The preclinical study demonstrated that the brain-targeted prodrug JHU395, derived from the glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON), effectively killed MYC-expressing medulloblastoma cells, increased survival in mice with MYC-amplified medulloblastoma tumors, and showed promise for further development as a potential treatment for medulloblastoma. [Read the Full Post]

Navoximod modulates local HSV-1 replication to reshape tumor immune microenvironment for enhanced immunotherapy via an injectable hydrogel

65 views | Nov 03 2023

The combination of Navoximod and HSV-1 loaded in an injectable hydrogel (V-Navo@gel) shows promise in enhancing viral replication, reshaping the tumor microenvironment, and improving therapeutic outcomes in hepatocellular carcinoma and rabbit orthotopic liver cancer models. [Read the Full Post]

Production of highly pure R,R-2,3-butanediol for biological plant growth promoting agent using carbon feeding control of Paenibacillus polymyxa MDBDO

148 views | Nov 03 2023

The study demonstrates the potential of Paenibacillus polymyxa MDBDO as a biological plant growth promoting agent and outlines a fermentation strategy for the production of highly pure R,R-2,3-butanediol (R,R-2,3-BDO) at high concentrations, which significantly stimulates the growth of soybean and strawberry seedlings. [Read the Full Post]

Comprehensive Analysis of the Expression, Prognostic Value, and Immune Infiltration Activities of GABRD in Colon Adenocarcinoma

87 views | Nov 03 2023

GABRD expression in colon adenocarcinoma is significantly elevated and correlated with advanced clinical stage, poor prognosis, immune cell infiltration patterns, and potential drug resistance. [Read the Full Post]

Heterogeneous effects of cytotoxic chemotherapies for platinum-resistant ovarian cancer

38 views | Nov 03 2023

This study found that the effectiveness of chemotherapy agents varied in platinum-resistant ovarian cancer patients based on tumor characteristics, such as histological type and platinum-free interval, as well as the use of bevacizumab. [Read the Full Post]

Novel pharmacotherapy targeting the positive symptoms of schizophrenia

36 views | Nov 02 2023

This manuscript provides an updated overview of novel pharmacotherapy targeting positive symptoms in schizophrenia, highlighting promising compounds and alternative biological systems for future research. [Read the Full Post]

Significance of PBRM1 mutation in disease progress and drug selection in clear cell renal cell carcinoma

56 views | Nov 02 2023

This study highlights the high prevalence of PBRM1 mutation in ccRCC, its association with advanced disease stages, and identifies potential therapeutic targets and pathways for personalized treatment. [Read the Full Post]

Improving the quality of multi-layer films based on furcellaran by immobilising active ingredients and impact assessment of the use of a new packaging material

38 views | Nov 02 2023

The study developed multi-layer films incorporating furcellaran and active ingredients, which showed improved water properties, inhibited microbial growth, but had limited effects on lipid oxidation, thus exhibiting potential as active packaging materials for extending the shelf-life of fish products. [Read the Full Post]

Ultrasound stiffness and perfusion markers correlate with tumor volume responses to immunotherapy

42 views | Nov 02 2023

This study demonstrates that ultrasound-derived measures of tumor stiffness and perfusion can serve as predictive biomarkers for the efficacy of immune checkpoint inhibition in cancer patients, providing valuable insights into the tumor microenvironment and aiding in the development of personalized treatment strategies. [Read the Full Post]

Pharmacological Characterization of P626, a Novel Dual Adenosine A2A/A2B Receptor Antagonist, on Synaptic Plasticity and during an Ischemic-like Insult in CA1 Rat Hippocampus

55 views | Nov 02 2023

The newly synthesized dual A2AAR/A2BAR antagonist, P626, demonstrated the ability to prevent A2AAR- and A2BAR-mediated effects and delay anoxic depolarization in a concentration-dependent manner, potentially making it a promising neuroprotective compound for stroke treatment. [Read the Full Post]

Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Cardiomyocyte Ferroptosis

53 views | Nov 01 2023

The study revealed that Alox15-mediated cardiomyocyte ferroptosis is a crucial factor in prolonged myocardial ischemia-reperfusion injury, and inhibiting Alox15 can protect the myocardium and promote cardiac function recovery. [Read the Full Post]

Design, synthesis and anti-Chikungunya virus activity of lomerizine derivatives

60 views | Nov 01 2023

The study demonstrated that Lomerizine (Lom) and its derivatives exhibited potent anti-CHIKV activity and low cytotoxicity, particularly compounds B1 and B7, suggesting their potential as effective anti-Chikungunya drugs. [Read the Full Post]