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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Enantioselectivity in the enzymatic dehydration of malate and tartrate: Mirror image specificities of structurally similar dehydratases

52 views | Feb 12 2024

The switch in substrate stereospecificity between fumarate hydratase and L-tartrate dehydratase may be attributed to subtle conformational adjustments and amino acid flexibility in the active site, potentially facilitated by the enantiomer superposition model. [Read the Full Post]

CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells

48 views | Feb 12 2024

The CD74-ROS1 L2026M mutation in NSCLC cells induces increased invasion, metastasis, and crizotinib resistance via the MEK/ERK pathway-mediated autophagy, highlighting MEK as a potential target for reversing these processes and enhancing treatment efficacy. [Read the Full Post]

Immunotactoid hepatopathy: A novel entity with histologically proven recurrence post liver transplantation

50 views | Feb 12 2024

This case of hepatic immunotactoid deposition following liver transplantation, managed with a Daratumumab-based regimen targeting underlying plasma-cell dyscrasia, exhibited encouraging outcomes in reducing serum paraproteins, resolving ascites, and improving kidney function without inducing rejection, showing promise for treating this rare complication. [Read the Full Post]

Vestibular Testing-New Physiological Results for the Optimization of Clinical VEMP Stimuli

95 views | Feb 12 2024

The review explores the intricate synaptic and receptor mechanisms of auditory and vestibular systems, proposing an "ultrafast" non-quantal transmission as the cause of rapid vestibular afferent responses, with profound implications for clinical testing and understanding neural processing in these sensory pathways. [Read the Full Post]

Diallyl disulfide synergizes with melphalan to increase apoptosis and DNA damage through elevation of reactive oxygen species in multiple myeloma cells

44 views | Feb 12 2024

The study underscores the potential of combining DADS, a compound found in garlic, with melphalan as a promising strategy for enhancing the efficacy of multiple myeloma treatment through induced apoptosis and increased DNA damage in MM cells. [Read the Full Post]

Hippocampal CaMKII inhibition induces reactivation-dependent amnesia for extinction memory and causes fear relapse

58 views | Feb 11 2024

Inhibition of hippocampal CaMKII activity post-fear extinction memory recall in rats disrupts extinction consolidation, facilitating GluN2B-NMDAR-dependent fear recovery, underscoring CaMKII's pivotal role in fear memory reconsolidation. [Read the Full Post]

The role of glutamate NMDA receptors of the mediodorsal thalamus in scopolamine-induced amnesia in rats

76 views | Feb 11 2024

This study demonstrates that activation of glutamate NMDA receptors in the mediodorsal thalamus mitigates scopolamine-induced memory impairment, while their blockade exacerbates this cognitive deficit, suggesting a pivotal role for the MD glutamatergic system via the NMDA receptor pathway in memory consolidation. [Read the Full Post]

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's

59 views | Feb 11 2024

The study elucidates that L-type voltage-gated calcium channels (LTCCs) govern dopamine release in a regionally and sexually divergent manner, influenced by multiple factors associated with either increased vulnerability or protection against Parkinson's disease. [Read the Full Post]

Heterostructured BiVO4/CoPi nanoarrays as high-efficiency photoanode and AuPt nanodendrites as nanozyme for sensitive sensing of miRNA 141

57 views | Feb 11 2024

A highly sensitive BiVO4/CoPi heterostructured PEC biosensor utilizing AuPt nanodendrites as a nanozyme has been developed, exhibiting a wide linear range from 5 fM to 1 pM and an ultra-low detection limit of 0.17 fM for miRNA 141, offering valuable prospects for precise tumor biomarker analysis in clinical applications. [Read the Full Post]

Effect of follicular wave synchronization using a progesterone-releasing intravaginal device-based protocol on in vitro embryo production in Bos taurus cows subjected to 14-day intervals ovum pick-up

33 views | Feb 11 2024

The study highlighted that follicular wave synchronization in Angus cows before ovum pick-up enhanced embryo quality while revealing sustained carryover effects on follicle numbers and cumulus-oocyte complex morphology. [Read the Full Post]

Ecological benefits of artificial light at night (ALAN): Accelerating the development and metamorphosis of marine shellfish larvae

98 views | Feb 10 2024

The comprehensive study on artificial light at night (ALAN) reveals a surprising positive impact of short-wavelength blue light on Pacific abalone embryonic development, offering crucial insights into the differential effects of light spectrums and their implications for marine benthic ecosystems. [Read the Full Post]

Targeting lncRNA NEAT1 Hampers Alzheimer's Disease Progression

41 views | Feb 10 2024

Knocking down lnc-NEAT1 in Alzheimer's disease models demonstrated reduced neuronal damage, inflammation, and oxidative stress through the mediation of microRNA-193a and activation of protective neuronal pathways. [Read the Full Post]

Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer

56 views | Feb 10 2024

The study elucidates the pivotal role of the HBP1/TIMP3 axis in suppressing breast cancer tumorigenesis and progression while enhancing sensitivity to radiation and hormone therapies, unveiling promising prospects for novel treatment modalities and improved prognostic approaches. [Read the Full Post]

Utilization, reimbursement, and price trends for Hepatitis C virus medications in the US Medicaid programs: 2001-2021

47 views | Feb 10 2024

The study delineates the shifting landscape of HCV treatment from conventional therapies to expensive yet effective DAA agents, emphasizing the critical role of treatment guidelines and policies in influencing market dynamics and accessibility despite persistent challenges in affordability. [Read the Full Post]

Effects of different chronic restraint stress periods on anxiety- and depression-like behaviors and tryptophan-kynurenine metabolism along the brain-gut axis in C57BL/6N mice

42 views | Feb 10 2024

Prolonged chronic stress induces anxiety and depression-like behaviors while altering the tryptophan-kynurenine metabolism in a manner that shifts towards neurotoxicity, highlighting the complex impact of stress duration on behavior and neurochemistry in mice. [Read the Full Post]

Three new phenolic glycosides and a new lignan glycoside from Gaultheria leucocarpa var. yunnanensis

53 views | Feb 09 2024

Compounds isolated from Gaultheria leucocarpa var. yunnanensis demonstrated significant anti-inflammatory and antioxidant properties, with compounds 7 and 8 showing promising inhibitory effects against LPS-induced NO production and compound 7 exhibiting notable DPPH radical scavenging activity. [Read the Full Post]

Cell-Penetrating Peptide-Bismuth Bicycles

104 views | Feb 09 2024

The development of peptide-bismuth bicycles as cell-penetrating peptides showcases a groundbreaking leap in cellular uptake efficiency, offering a promising avenue for diverse biomedical applications. [Read the Full Post]

Engineering the cofactor binding site of 7α-hydroxysteroid dehydrogenase for improvement of catalytic activity, thermostability, and alteration of substrate preference

34 views | Feb 09 2024

The targeted mutations at the cofactor binding site of Hydroxysteroid dehydrogenase (HSDH) St-2-2 not only significantly enhanced catalytic activity, altered substrate preference, and increased thermostability but also provided valuable insights into modifying enzymatic properties, offering potential applications in disease treatment through engineered bacteria. [Read the Full Post]

Establishment of a Rapid and Effective Agrobacterium-Mediated Genetic Transformation System of Oxalis triangularis 'Purpurea'

29 views | Feb 09 2024

Your study's refined transformation protocol for Oxalis triangularis 'Purpurea' opens new avenues for comprehensive gene function studies and enhances the potential for genetic manipulation in ornamental plants. [Read the Full Post]

Sibutramine-Induced Nonischemic Cardiomyopathy

83 views | Feb 09 2024

The case report of sibutramine-induced nonischemic cardiomyopathy in a young individual underscores the critical need for safer anti-obesity medications and vigilant patient monitoring to mitigate severe cardiovascular risks associated with pharmacotherapy. [Read the Full Post]