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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

The histone acetyltransferase Mof regulates Runx2 and Osterix for osteoblast differentiation

40 views | Oct 08 2023

The study reveals that the histone acetyltransferase Mof functions as a novel regulator of osteoblast differentiation by promoting the expression of osteogenic markers Runx2 and Osterix, suggesting its potential as a therapeutic target for conditions like osteosarcoma and osteoporosis. [Read the Full Post]

Effects of the factor Xa inhibitor rivaroxaban on the differentiation of endothelial progenitor cells

40 views | Oct 08 2023

The study demonstrated that rivaroxaban treatment increased the differentiation ability of vascular endothelial progenitor cells (EPCs), suggesting its potential for improving vascular repair in patients with coronary artery disease. [Read the Full Post]

The Heart Failure Knights

47 views | Oct 08 2023

The 2021 European Society of Cardiology guidelines have introduced a four-pillar approach for optimal drug therapy in heart failure, and emerging molecules such as vericiguat, omecamtiv mecarbil, mavacamten, and aficamten show promise in improving outcomes for patients with reduced ejection fraction heart failure. [Read the Full Post]

The Functional Role and Regulatory Mechanism of FTO m6A RNA Demethylase in Human Uterine Leiomyosarcoma

126 views | Oct 08 2023

In summary, the study highlights the aberrant upregulation of FTO m6A RNA demethylase in uterine leiomyosarcoma tissues and demonstrates that inhibiting FTO with Dac51 can significantly decrease uLMS cell proliferation, modulate key pathways, and potentially offer a novel therapeutic strategy for this aggressive uterine cancer. [Read the Full Post]

SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA

96 views | Oct 08 2023

The discovery that the survival and growth of AML cells, irrespective of their genetic characteristics, rely on SIRT5 highlights its potential as a therapeutic target for AML treatment. [Read the Full Post]

Tamoxifen resistance induction results in the upregulation of ABCG2 expression and mitoxantrone resistance in MCF-7 breast cancer cells

184 views | Oct 07 2023

The study found that prolonged exposure of ER+ MCF-7 breast cancer cells to tamoxifen led to increased expression of the ABCG2 pump, associated with TAM resistance and potential cross-resistance to mitoxantrone. [Read the Full Post]

Dexamethasone and OLT1177 Cooperate in the Reduction of Melanoma Growth by Inhibiting STAT3 Functions

51 views | Oct 07 2023

The combination of OLT1177 and dexamethasone effectively reduces tumor growth by targeting both the nuclear and mitochondrial functions of STAT3, accompanied by downregulation of STAT3-dependent gene transcription and significant reductions in STAT3 phosphorylation. [Read the Full Post]

Bioassay-Guided Isolation of Anthelmintic Components from Semen pharbitidis, and the Mechanism of Action of Pharbitin

52 views | Oct 07 2023

This study identified the anthelmintic compound pharbitin from Semen pharbitidis and revealed that its target in Caenorhabditis elegans is likely UNC-63, supporting the traditional use of Semen pharbitidis for treating intestinal parasites. [Read the Full Post]

Anti-hepatocellular carcinoma activity of the cyclin-dependent kinase inhibitor AT7519

140 views | Oct 07 2023

The research findings suggest that AT7519, a CDK inhibitor, shows potential as a monotherapy or in combination with drugs like gefitinib or cabozantinib, to improve the effectiveness of treatments for hepatocellular carcinoma. [Read the Full Post]

The purinergic receptors 2X3 on spiral ganglion neurons enhance the medial olivocochlear reflex in mice after long-term moderate noise exposure

102 views | Oct 07 2023

Long-term moderate noise exposure increases the expression of P2X3 receptors in spiral ganglion neurons (SGNs) and enhances the medial olivocochlear (MOC) reflex, which can be downregulated by AF-353, a specific antagonist for P2X3 receptors. [Read the Full Post]

Application of sulfoximines in medicinal chemistry from 2013 to 2020

39 views | Oct 06 2023

The comprehensive review of relevant articles on sulfoximines' potency and pharmacokinetic properties from 2013 to the present aims to support the incorporation of the sulfoximine component into the toolkit of medicinal chemists by addressing the limited experience in physicochemical and in vitro parameters of sulfoximines. [Read the Full Post]

Cell surface ATP synthase-released H+ and ATP play key roles in cocoa butter intake-mediated regulation of gut immunity through releases of cytokines in rat

105 views | Oct 06 2023

Cocoa butter intake regulates gut immunity by increasing lymph flow, cell density, and the release of IL-1β, IL-6, and IL-10 in mesenteric lymph, with the involvement of macrophages, cell surface ATP synthase, and pH-dependent cytokine release. [Read the Full Post]

Tamoxifen pharmacokinetics and pharmacodynamics in older patients with non-metastatic breast cancer

40 views | Oct 06 2023

In older women with non-metastatic breast cancer, higher concentrations of tamoxifen and its metabolites were observed, independent of CYP2D6 and CYP3A4 gene polymorphisms, but these differences did not have a significant impact on clinical outcomes. [Read the Full Post]

Antibiotic Susceptibility Profile of Bacteria Causing Aerobic Vaginitis in Women in Iraq

113 views | Oct 06 2023

The study revealed high rates of antimicrobial resistance among bacterial isolates from women with aerobic vaginitis, with Gram-positive bacteria showing resistance to penicillins and cephalosporins and Gram-negative bacteria displaying resistance to multiple antibiotic classes. [Read the Full Post]

Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin

95 views | Oct 06 2023

The study confirms that GPX4 acts as an oncogene, inhibits ferroptosis in cancer cells, and its inhibition enhances the anticancer effect of cisplatin. [Read the Full Post]

Ultrasound-triggered in situ gelation with ROS-controlled drug release for cartilage repair

66 views | Oct 05 2023

A novel ROS-responsive in situ nanocomposite hydrogel loaded with kartogenin (KGN) and bone marrow-derived stem cells (BMSCs) effectively promotes chondrogenic differentiation and improves cartilage regeneration, offering potential for efficient cartilage repair. [Read the Full Post]

The First Case of Human Hepatic Fasciolosis Presented as Hepatic Pseudotumor Histopathologically Diagnosed in Romania-A Case Report

75 views | Oct 05 2023

The case report highlights the importance of considering fasciolosis as a potential diagnosis even in areas where it is not commonly observed, emphasizing the need for careful evaluation in patients presenting with relevant symptoms. [Read the Full Post]

Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles

142 views | Oct 05 2023

The paper presents the development of RGD-(NPGP/CS)3NPGP nanoparticles through layer-by-layer assembly, which demonstrate high encapsulation efficiency, pH-sensitive release, and effective targeting to integrin receptor-expressing tumor cells, making them promising as novel anticancer drug carriers. [Read the Full Post]

Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation

94 views | Oct 05 2023

Nr4a1 promotes renal fibrosis by activating p38 MAPK, as evidenced by its upregulation in a mouse model of renal interstitial fibrosis, its correlation with fibrotic protein levels, and the exacerbation of fibrosis by Nr4a1 activation and its inhibition by p38 MAPK blockade. [Read the Full Post]

Translation-dependent skin hyperplasia is promoted by type 1/17 inflammation in psoriasis

153 views | Oct 05 2023

This study reveals that the molecule eukaryotic initiation factor 4E (eIF4E) plays a crucial role in the abnormal differentiation of keratinocytes driven by type 1/17 inflammation in psoriasis, suggesting its potential as a therapeutic target. [Read the Full Post]