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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis

53 views | Oct 24 2023

This study demonstrates that targeting N-glycosylation of SLAMF7 through an antibody-drug conjugate can enhance antibody affinity and phagocytosis, potentially improving the response of immunotherapeutic agents in breast cancer treatment. [Read the Full Post]

Antioxidative polyphenols attenuate pyocyanin-induced ROS production in neuronal HT22 cell lines

120 views | Oct 24 2023

This study demonstrates that pyocyanin-induced neuronal damage can be mitigated by specific polyphenols, suggesting their potential as therapeutic agents for ROS-related neurological diseases. [Read the Full Post]

Relationship among cattle breed and anabolic implant protocol relative to feedlot performance: Growth, temperament, feeding behavior, carcass traits, and economic return

88 views | Oct 24 2023

The study found that a moderate intensity anabolic implant protocol was optimal for feedlot steers of different breed types, resulting in increased average daily gain and higher net return per head compared to non-implanted and high intensity implant groups in a temperate climate. [Read the Full Post]

The copper chelator ammonium tetrathiomolybdate inhibits the progression of experimental endometriosis in TNFR1-deficient mice

44 views | Oct 24 2023

Treatment with ammonium tetrathiomolybdate (TM), a copper chelator, inhibits the progression of endometriosis in TNFR1-deficient mice by restoring copper and estradiol levels, reducing lesion size, inhibiting cell proliferation and angiogenesis, and modulating oxidative stress markers. [Read the Full Post]

[ANMCO Expert opinion: Bempedoic acid place in therapy for hypercholesterolemia management]

108 views | Oct 24 2023

Bempedoic acid, a newly approved therapeutic option for hypercholesterolemia, offers a hepatic selective action that reduces the risk of muscle adverse effects, making it particularly useful in certain clinical settings according to an ANMCO document. [Read the Full Post]

Lipid Peroxidation and Antioxidative Capacity Are Unaltered in Transitional Breast Milk Exposed to Light from Women Giving Birth to Preterm Infants before 32 Weeks of Gestation

65 views | Oct 23 2023

The study found that light exposure of expressed transitional breast milk did not significantly affect lipid peroxidation or the levels of malondialdehyde, 4-hydroxynonenal, or total antioxidant capacity. [Read the Full Post]

Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants

126 views | Oct 23 2023

Stenoparib (2X-121), a poly (ADP-ribose) polymerase (PARP) inhibitor, demonstrates effective inhibition of SARS-CoV-2 and its variant strains in vitro, with the potential for enhanced antiviral activity when combined with remdesivir. [Read the Full Post]

Pak1 pathway hyper-activation mediates resistance to endocrine therapy and CDK4/6 inhibitors in ER+ breast cancer

104 views | Oct 23 2023

This study demonstrates that p21-activated kinase 1 (Pak1) plays a crucial role in resistance to estrogen receptor antagonists and CDK4/6 inhibitors in estrogen receptor-positive (ER+) breast cancer, suggesting the potential for Pak1 inhibitors as a therapeutic approach for patients with ER+ breast cancer who have become resistant to current treatments. [Read the Full Post]

Effect of budesonide on pulmonary activity of multidrug resistance-associated protein 1 assessed with PET imaging in rats

65 views | Oct 23 2023

Intratracheal aerosolized budesonide, even at a dose approximately five times higher than the maximum clinical dose, did not affect pulmonary MRP1 activity in rats, suggesting no impact on the MRP1-mediated detoxifying capacity of the lungs, while the model MRP1 inhibitor MK571 exhibited a significant inhibitory effect. [Read the Full Post]

Dehydrocorydaline Protects Against Sepsis-Induced Myocardial Injury Through Modulating the TRAF6/NF-κB Pathway

64 views | Oct 23 2023

Dehydrocorydaline (Deh) treatment effectively mitigates sepsis-induced myocardial injury by inhibiting the TRAF6/NF-κB pathway, demonstrating its potential as a therapeutic intervention. [Read the Full Post]

Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes

62 views | Oct 22 2023

The study identified increased expression of the neuropeptide Y1 receptor in human islets from subjects with type 2 diabetes, which was associated with reduced insulin secretion, and demonstrated that treatment with the Y1 receptor antagonist BIBO3304 improved beta-cell function, preserved beta-cell mass, and resulted in better glycemic control in mouse models of type 2 diabetes. [Read the Full Post]

RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer

123 views | Oct 22 2023

Silencing of RNA binding motif protein 15 (RBM15) promotes ferroptosis and inhibits lung cancer cell growth through the TGF-β/Smad2 pathway, offering potential therapeutic implications for lung cancer treatment. [Read the Full Post]

Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome

107 views | Oct 22 2023

The study identified CAY10603, an HDAC6 inhibitor, as a potential therapeutic drug for diabetic nephropathy by suppressing NLRP3 inflammasome activation in tubular cells and macrophages. [Read the Full Post]

ADME Prediction, Structure-activity Relationship of Boswellic Acid Scaffold for the Aspect of Anticancer & Anti-inflammatory Potency

49 views | Oct 22 2023

Boswellic acid and its analogs, particularly 11-keto-β-boswellic acid (KBA) and 3-O-acetyl-11-keto-β-boswellic acid (AKBA), exhibit promising therapeutic potential as anti-inflammatory and anticancer agents, with computational ADME prediction and structure-activity relationship analysis providing valuable insights into their pharmacokinetics and biological effects. [Read the Full Post]

[p53 regulates primordial follicle activation through the mTOR signaling pathway]

179 views | Oct 22 2023

This study demonstrated that p53 inhibits primordial follicle activation through the mTOR signaling pathway, thereby maintaining the reserve of primordial follicles. [Read the Full Post]

SIRT6 ameliorates LPS-induced apoptosis and tight junction injury in ARDS through the ERK1/2 pathway and autophagy

110 views | Oct 21 2023

SIRT6, through its regulation of the ERK1/2 pathway and enhancement of autophagy, demonstrates a beneficial role in acute respiratory distress syndrome (ARDS) by ameliorating tight junction protein loss, inflammation, and apoptosis, suggesting its potential as a therapeutic target for ARDS. [Read the Full Post]

Double crosslinked biomimetic composite hydrogels containing topographical cues and WAY-316606 induce neural tissue regeneration and functional recovery after spinal cord injury

90 views | Oct 21 2023

The study presents a multifunctional biomaterial system composed of acellularized spinal cord matrix, gelatin-acrylated-β-cyclodextrin-polyethene glycol diacrylate hydrogel, and aligned polycaprolactone microfibers, loaded with WAY-316606, which effectively promotes neural tissue regeneration and significantly improves motor function in rats with spinal cord injury. [Read the Full Post]

[Efficacy of Tyrosine Kinase Inhibitor Combined with Decitabine, Homoharringtonine, Interferon in the Maintenance Therapy of Blast Phase Chronic Myeloid Leukemia]

105 views | Oct 21 2023

The combination of tyrosine kinase inhibitor (TKI) with decitabine, homoharringtonine, and interferon as maintenance therapy significantly prolongs event-free survival, duration of remission, and overall survival in blast phase chronic myeloid leukemia (CML-BP) patients who have achieved a major hematological response compared to TKI combined with conventional chemotherapy. [Read the Full Post]

Potential for cardiac toxicity with methylimidazolium ionic liquids

57 views | Oct 21 2023

This study suggests that Methylimidazolium ionic liquids (MILs) have the potential to cause cardiotoxicity in rats, while mice may be less sensitive to MIL-induced cardiac toxicity due to higher expression and/or function of cardiac transport proteins, highlighting potential hazards of MIL exposure in humans if their use levels increase. [Read the Full Post]

Lipid profile changes associated with antiretroviral therapies in a real-world cohort

49 views | Oct 21 2023

In this retrospective cohort study, treatment with elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate was associated with a significant worsening of the lipid profile compared to dolutegravir/abacavir/lamivudine, but no significant differences in cardiovascular events were observed between the two treatment groups. [Read the Full Post]