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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Muscle-Specific Ablation of Glucose Transporter 1 (GLUT1) Does Not Impair Basal or Overload-Stimulated Skeletal Muscle Glucose Uptake

197 views | Apr 15 2023

The study found that GLUT1 is not necessary for basal muscle glucose uptake and suggests a novel glucose transport mechanism mediates overload-stimulated glucose uptake. [Read the Full Post]

5-Oxoproline Enhances 4-Hydroxytamoxifen-induced Cytotoxicity by Increasing Oxidative Stress in MCF-7 Breast Cancer Cells

154 views | Apr 15 2023

The study found that 5-oxoproline (5-OP) enhances 4-hydroxytamoxifen (4-OHT)-induced cytotoxicity in estrogen receptor (ER)-positive breast cancer cells under normal glucose conditions, while the selective monocarboxylate transporter (MCT) 4 inhibitor Bindarit decreased 4-OHT sensitivity, and MCT1 expression increased under normal glucose conditions. [Read the Full Post]

TRPM4 gene variation associated with climatic conditions in Chinese cattle

99 views | Apr 15 2023

The study suggests that a missense mutation in the TRPM4 gene is associated with heat tolerance in Chinese cattle and could be a candidate locus for further investigation. [Read the Full Post]

Investigation of the impact of rosuvastatin and telmisartan in doxorubicin-induced acute cardiotoxicity

157 views | Apr 15 2023

The study found that pre-treatment with rosuvastatin and telmisartan, alone or in combination, showed significant cardio-protective effects against the acute cardiotoxicity induced by doxorubicin. [Read the Full Post]

Effects of Modulation of the Hedgehog and Notch Signaling Pathways on Osteoblast Differentiation Induced by Titanium with Nanotopography

93 views | Apr 15 2023

This study demonstrates that Hedgehog and Notch signalling pathways modulate osteoblast differentiation and regulate receptor expression on nanostructured titanium surfaces, with synergistic effects observed with the combination of Hedgehog activation and Notch inhibition. [Read the Full Post]

A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis

169 views | Apr 14 2023

The review provides information on natural plant sources for combating avian influenza in chickens and identifies potential targets for future drug development. [Read the Full Post]

Association of reported NSAID adverse drug reactions with opioid prescribing following total joint arthroplasty

153 views | Apr 14 2023

This retrospective cohort study found that reported adverse drug reactions to nonsteroidal anti-inflammatory drugs were associated with an increased risk of prolonged receipt of opioids following total joint arthroplasty. [Read the Full Post]

Romidepsin-induced durable remission for relapsed nodal peripheral T-cell lymphoma with T follicular helper phenotype after allogeneic hematopoietic cell transplantation

117 views | Apr 14 2023

This case report suggests that romidepsin may be a safe and effective treatment option for patients with relapsed or refractory PTCL-TFH after allogeneic HCT. [Read the Full Post]

An efficient transformation method for tannin-containing sorghum

132 views | Apr 14 2023

The successful establishment of an efficient microprojectile transformation system for tannin-containing sorghum using immature embryos of Hongyingzi as explants offers the possibility of breaking the restriction imposed by tannins in plants and improving the nutritional value and potential of sorghum as a food and feed crop. [Read the Full Post]

A Versatile Toolset for Genetic Manipulation of the Wine Yeast Hanseniaspora uvarum

85 views | Apr 14 2023

The passage describes the development of a toolset for efficient and targeted genetic manipulation of the yeast species Hanseniaspora uvarum, which includes the creation of homozygous auxotrophic deletion markers, self-replicating cloning vectors, and a chemical transformation procedure. [Read the Full Post]

Modulation of the endoplasmic reticulum stress and unfolded protein response mitigates the behavioral effects of early-life stress

193 views | Apr 13 2023

The study suggests that modulation of ER stress and UPR processes may underlie susceptibility or resilience to early-life stress (ELS) in rats. [Read the Full Post]

Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson's disease

77 views | Apr 13 2023

The study found that short-term therapy with high-dose nicotinamide riboside (NR) for up to 30 days had no negative impact on DNA methylation homeostasis in individuals with Parkinson's disease. [Read the Full Post]

GW-2974 and SCH-442416 modulators of tyrosine kinase and adenosine receptors can also stabilize human telomeric G-quadruplex DNA

127 views | Apr 13 2023

GW-2974 and SCH-442416 could stabilize human telomeric G-quadruplex DNA in addition to their known tyrosine kinase and adenosine receptor modulation properties, suggesting that stabilizing G-quadruplex DNA could be a potential mechanism underlying their anti-cancer activity. [Read the Full Post]

Trends in the Use of Oral Anticoagulants for Adults With Venous Thromboembolism in the US, 2010-2020

72 views | Apr 13 2023

This retrospective cohort study using data from two US health insurance databases evaluated prescribing patterns of oral anticoagulants for patients with venous thromboembolism and identified clinical events that preceded treatment changes, highlighting the importance of identifying reasons for treatment modification for valid evidence on drug safety and effectiveness. [Read the Full Post]

Papain Exerts an Anti-atherosclerosis Effect with Suppressed MPA-mediated Foam Cell Formation by Regulating the MAPK and PI3K/Akt-NF-κB Pathways

210 views | Apr 13 2023

The study found that papain inhibits MPA-induced foam cell formation by inactivating the MAPK and PI3K/Akt-NF-κB pathways, thereby exerting an anti-AS effect. [Read the Full Post]

Pirfenidone suppresses tumor necrosis factor-alpha, enhances interleukin-10 and protects mice from endotoxic shock

156 views | Apr 12 2023

The study found that pirfenidone provided prophylactic and therapeutic benefits for murine endotoxic shock by inhibiting pro-inflammatory cytokines, enhancing interleukin-10, and suppressing apoptotic cells and TGF-beta1 in the liver. [Read the Full Post]

A highly efficient genetic transformation system for broccoli and subcellular localization

96 views | Apr 12 2023

This study provides new insights into the improvement of the genetic transformation and molecular breeding of broccoli, which could lead to the development of improved crop varieties with enhanced traits. [Read the Full Post]

O-linked N-acetylglucosamine modification induced by lipopolysaccharide is involved in inflammatory signaling pathway in endothelial cells

71 views | Apr 12 2023

The study investigated the involvement of O-GlcNAc modification in the inflammatory signaling pathway of endothelial cells under LPS stimulation and found that increasing OGT expression could inhibit the activation of the inflammatory signal pathway and reduce inflammatory cytokine expression, and that the PI3K/Akt pathway is involved in regulating O-GlcNAc modification in response to LPS stimulation. [Read the Full Post]

Regulation of programmed death ligand 1 expression by interferon-γ and tumour necrosis factor-α in canine tumour cell lines

110 views | Apr 12 2023

The study demonstrates that upregulation of PD-L1 expression in canine tumours is regulated by the JAK-STAT and NF-κB signaling pathways upon stimulation with IFN-γ and TNF-α, respectively. [Read the Full Post]

[A convenient and time-saving method for primary culture of mature white adipocytes from mice]

133 views | Apr 12 2023

The study established a simple, low-cost, and time-saving method for primary culture of mature white adipocytes from mice, enabling further functional studies. [Read the Full Post]