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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Inhibiting CBX4 efficiently protects hepatocellular carcinoma cells against sorafenib resistance

39 views | Jan 03 2024

Blocking CBX4 expression appears pivotal in addressing sorafenib resistance in advanced hepatocellular carcinoma, with miR424 and its suppression of CBX4 revealing potential therapeutic avenues. [Read the Full Post]

Bestatin, A Pluripotent Immunomodulatory Small Molecule, Drives Robust and Long-Lasting Immune Responses as an Adjuvant in Viral Vaccines

55 views | Jan 03 2024

The inclusion of bestatin as an adjuvant in inactivated foot-and-mouth disease vaccines significantly enhances immune response in experimental animals, showcasing its potential to improve vaccine efficacy and induce long-lasting immunity. [Read the Full Post]

Quantitative Proteomics Characterization of the Effect and Mechanism of Trichostatin A on the Hippocampus of Type II Diabetic Mice

68 views | Jan 03 2024

The study demonstrates Trichostatin A's potential in improving cognitive function in diabetic encephalopathy by modulating key proteins and pathways, highlighting its promise as a therapeutic intervention and suggesting potential similar and ancillary drugs for treatment. [Read the Full Post]

Evaluation of Histone Demethylase Inhibitor ML324 and Acyclovir against Cyprinid herpesvirus 3 Infection

0 views | Jan 03 2024

ML324 demonstrates significant potential as an effective treatment against Cyprinid herpesvirus 3 (CyHV-3) infection in koi fish, outperforming traditional antiviral drugs like acyclovir in inhibiting virus replication both in vitro and in vivo. [Read the Full Post]

TH-302-loaded nanodrug reshapes the hypoxic tumour microenvironment and enhances PD-1 blockade efficacy in gastric cancer

44 views | Jan 03 2024

TH-302 nanoparticles show promise in alleviating the hypoxic tumor microenvironment and enhancing the efficacy of PD-1 blockade, presenting a safe and effective combined immunotherapy approach for gastric cancer treatment. [Read the Full Post]

Fabrication and characterization of dihydromyricetin-loaded microcapsules stabilized by glyceryl monostearate and whey protein-xanthan gum

167 views | Jan 02 2024

Encapsulation of dihydromyricetin using glyceryl monostearate and octyl/decyl glycerate as inner cores, whey protein, and xanthan gum as wall materials demonstrated enhanced stability, controlled release, and improved antioxidant effects, presenting a promising strategy for delivering lipophilic bioactive compounds with heightened bioavailability and stability. [Read the Full Post]

Runx3 Restoration Regresses K-Ras-Activated Mouse Lung Cancers and Inhibits Recurrence

124 views | Jan 02 2024

The study's findings suggest that the restoration of RUNX3 presents a promising therapeutic avenue for effectively treating K-RAS-activated lung cancers by regressing tumors and suppressing recurrence through multifaceted pathways, potentially offering a durable response. [Read the Full Post]

Serum macrophage migration inhibitory factor levels predict brain atrophy in people with primary progressive multiple sclerosis

59 views | Jan 02 2024

Baseline serum MIF levels in primary progressive MS correlated with faster brain atrophy, showing a sex disparity with higher levels in males, while ibudilast treatment didn't significantly alter MIF levels. [Read the Full Post]

Epigenetic Compound Screening Uncovers Small Molecules for Reactivation of Latent HIV-1

123 views | Jan 02 2024

The study utilized a cell-based reporter system under BSL-1 conditions to screen an epigenetic compound library, identifying two promising compounds, HPOB and SR-4370, with high reactivation efficiencies and low toxicity, offering potential as effective treatments for reversing HIV-1 latency. [Read the Full Post]

Rapid Formation of Intramolecular Disulfide Bridges using Light: An Efficient Method to Control the Conformation and Function of Bioactive Peptides

54 views | Jan 02 2024

The light-mediated strategy utilizing 2-nitroveratryl (oNv) for controlled disulfide bond formation in peptides offers precise spatiotemporal regulation, enabling the restoration of native structures and functions, showcasing potential for targeted therapies and smart biomaterial design. [Read the Full Post]

Comprehensive analysis of angiogenesis pattern and related immune landscape for individual treatment in osteosarcoma

73 views | Jan 01 2024

The ANGscore, a novel prognostic model based on angiogenesis patterns in osteosarcoma, not only accurately predicts patient outcomes and immune characteristics but also holds promise in guiding personalized treatment strategies and immunotherapy responses for better clinical management. [Read the Full Post]

FGF2 positively regulates osteoclastogenesis via activating the ERK-CREB pathway

0 views | Jan 01 2024

FGF2 influences bone homeostasis by stimulating osteoclastogenesis via the ERK-CREB pathway, suggesting potential therapeutic avenues for bone-related disorders like osteoporosis through targeted inhibition of this signaling cascade. [Read the Full Post]

In Silico Study on the Interactions, Molecular Docking, Dynamics and Simulation of Potential Compounds from Withania somnifera (L.) Dunal Root against Cancer by Targeting KAT6A

39 views | Jan 01 2024

The study on Withania somnifera compounds demonstrates promising anticancer potential through molecular interactions with KAT6A and validated inhibitory effects on human breast cancer cells, validating the traditional use of W. somnifera as an effective anticancer herb. [Read the Full Post]

GSNOR deficiency attenuates MPTP-induced neurotoxicity and autophagy by facilitating CDK5 S-nitrosation in a mouse model of Parkinson's disease

39 views | Jan 01 2024

The study revealed that increased S-nitrosoglutathione reductase (GSNOR) expression in an MPTP-induced Parkinson's disease mouse model heightened CDK5-mediated autophagy and neurotoxicity, while GSNOR deficiency or inhibition alleviated PD-like pathology by inhibiting CDK5 activity through increased S-nitrosation at Cys83. [Read the Full Post]

Mechanism of Nrf2/miR338-3p/TRAP-1 pathway involved in hyperactivation of synovial fibroblasts in patients with osteoarthritis

99 views | Jan 01 2024

The identification of the Nrf2/miR338-3p/TRAP-1 pathway as a key regulator of hyperactivation in osteoarthritic synovial fibroblasts unveils promising therapeutic prospects and potential new drug targets for managing osteoarthritis. [Read the Full Post]

Combination of RSK inhibitor LJH-685 and FLT3 inhibitor FF-10101 promoted apoptosis and proliferation inhibition of AML cell lines

61 views | Dec 31 2023

The synergistic effect of RSK inhibitor LJH-685 in combination with FLT3 inhibitor FF-10101 demonstrates promising therapeutic potential against FLT3-ITD mutated AML by targeting the MAPK-RSKs-YB-1 signaling pathway, offering new avenues for effective intervention in drug-resistant AML. [Read the Full Post]

Active Components of Leontopodium alpinum Callus Culture Extract for Blue Light Damage in Human Foreskin Fibroblasts

253 views | Dec 31 2023

Research on Leontopodium alpinum callus culture extract's components, particularly leontopodic acid A, reveals promising potential in protecting skin cells from blue light damage, offering avenues for future skincare and pharmaceutical developments. [Read the Full Post]

P7C3-A20 treats traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis

54 views | Dec 31 2023

"P7C3-A20 treatment post-traumatic brain injury in rats exhibited neuroprotective effects by mitigating excessive autophagy and apoptosis, as evidenced by improved neurological deficits, reduced neuronal damage, and specific alterations in key protein expressions associated with these cellular processes." [Read the Full Post]

Evolution of Ritlecitinib Population Pharmacokinetic Models During Clinical Drug Development

110 views | Dec 31 2023

The iterative development of a population pharmacokinetic model for ritlecitinib, integrating data from diverse clinical trials, culminated in a refined two-compartment model with direct-response non-stationary clearance, informing critical clinical decisions and shaping the drug's label across varied conditions. [Read the Full Post]

Identification of CXCR4 Upregulation in Diffuse Large B-Cell Lymphoma Associated with Prognostic Significance and Clinicopathological Characteristics

83 views | Dec 31 2023

The upregulation of CXCR4 in activated B-cell-like DLBCL, associated with poorer prognosis, suggests CXCR4 as a potential therapeutic target, warranting further investigation and potential clinical trials for DLBCL treatment. [Read the Full Post]