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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Senolytic Combination Treatment Is More Potent Than Single Drugs in Reducing Inflammatory and Senescence Burden in Cells from Painful Degenerating IVDs

87 views | Nov 09 2023

Combining the senolytic drugs o-Vanillin and RG-7112 effectively removes senescent cells, reduces inflammation and pain mediators, and inhibits neuronal sprouting, offering promise as a potential treatment for low back pain associated with intervertebral disc degeneration. [Read the Full Post]

Staphylococcus aureus Infection Initiates Hypoxia-Mediated Transforming Growth Factor-β1 Upregulation to Trigger Osteomyelitis

96 views | Nov 09 2023

This study reveals a novel signaling cascade involving hypoxia/HIF-1α/TGF-β1 in the pathogenesis of Staphylococcus aureus-induced osteomyelitis, highlighting its potential as a therapeutic target for the condition. [Read the Full Post]

Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions

44 views | Nov 09 2023

The study identified GA-017, a small molecule inhibitor of large tumor suppressor kinases, which promotes cell proliferation in 3D culture systems by stabilizing and translocating key effectors of the Hippo signaling pathway, offering promising prospects for enhancing the efficiency of 3D cell culture and organoid expansion. [Read the Full Post]

Combined inhibition of aurora kinases and Bcl-xL induces apoptosis through select BH3-only proteins

222 views | Nov 08 2023

The study demonstrates that combining small-molecule inhibitors of AURK with BH3-mimetic inhibitors targeting Bcl-xL potently induces apoptosis and may overcome resistance to AURK inhibitors in colon cancer cells. [Read the Full Post]

Peripheral Arterial Thrombosis following Russell's Viper Bites

67 views | Nov 08 2023

This study reports three serious cases of peripheral arterial thrombosis following Russell's viper bites, emphasizing the significance of this complication in snakebite victims, while providing clinical management insights and mechanistic understanding of the procoagulant effects of Russell's viper venom. [Read the Full Post]

Novel small molecule inhibitors of the transcription factor ETS-1 and their antitumor activity against hepatocellular carcinoma

68 views | Nov 08 2023

This study identified four novel small molecule inhibitors of the transcription factor ETS-1, demonstrating their potential to suppress HCC cell proliferation and invasion, offering safer and more effective therapeutic strategies for hepatocellular carcinoma. [Read the Full Post]

Efficacy and safety of irinotecan combined with raltitrexed or irinotecan monotherapy for salvage chemotherapy of esophageal squamous cell cancer: A prospective, open label, randomized phase II study

102 views | Nov 08 2023

The combination of irinotecan and raltitrexed may lead to better progression-free survival and overall survival compared to irinotecan monotherapy, especially in the second-line treatment of metastatic esophageal squamous cell cancer. [Read the Full Post]

Identification of inhibitors for the transmembrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation

39 views | Nov 08 2023

The study demonstrates that the TcK2 protein kinase in Trypanosoma cruzi plays a crucial role in parasite proliferation and differentiation, and Dasatinib shows potential as a lead inhibitor for developing therapeutics targeting TcK2 in the treatment of Chagas disease. [Read the Full Post]

Targeting GSTP1 as Therapeutic Strategy against Lung Adenocarcinoma Stemness and Resistance to Tyrosine Kinase Inhibitors

157 views | Nov 07 2023

The study reveals that upregulation of Glutathione S-transferase pi (GSTP1) in lung adenocarcinoma (LUAD) supports cancer stem cells, tumor self-renewal, metastasis, and resistance to targeted therapies, making it a promising therapeutic target for long-term control of LUAD. [Read the Full Post]

The expanding role of IAP antagonists for the treatment of head and neck cancer

76 views | Nov 07 2023

IAP antagonists, also known as SMAC mimetics, have shown promising results in preclinical and clinical studies as potential anti-cancer therapeutics for head and neck squamous cell carcinomas (HNSCC), particularly when combined with radiation therapy. [Read the Full Post]

SUMOylation of Rho-associated protein kinase 2 induces goblet cell metaplasia in allergic airways

41 views | Nov 07 2023

The study reveals that protein SUMOylation-mediated activation of ROCK2, facilitated by PIAS1 and involving Rho/ROCK signaling, is a key mechanism in the development of goblet cell metaplasia in allergic asthma, suggesting that targeting SUMOylation could be a potential therapeutic intervention for the disease. [Read the Full Post]

Circulating small extracellular vesicles promote proliferation and migration of vascular smooth muscle cells via AXL and MerTK activation

0 views | Nov 07 2023

This study reveals that circulating small extracellular vesicles (csEVs) enhance the proliferation and migration of vascular smooth muscle cells (VSMCs) through phosphatidylserine (PS) interactions, and targeting the AXL and MerTK receptors may provide a viable approach for treating vascular diseases associated with neointima formation. [Read the Full Post]

Antitumor activity of withaferin-A and propolis in benz (a) pyrene-induced breast cancer

59 views | Nov 07 2023

The study demonstrated that the combination of Withaferin-A and propolis resulted in a decrease in plasma carcinoembryonic antigen (CEA) levels, indicating a potentially beneficial role in Benz(a)pyrene-induced breast cancer. [Read the Full Post]

Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of Concern

34 views | Nov 06 2023

The combination of pamapimod and pioglitazone has shown potent and synergistic activity in inhibiting SARS-CoV-2 replication in vitro, suggesting its potential as a therapy for reducing the duration and severity of COVID-19 in patients, pending further evaluation in ongoing clinical studies. [Read the Full Post]

EAT-2 attenuates C. elegans development via metabolic remodeling in a chemically defined food environment

26 views | Nov 06 2023

This study revealed that specific fatty acids, including C17ISO, palmitic acid, and stearic acid, as well as metabolites such as S-adenosylmethionine and methionine sulfoxide, can counteract the developmental attenuation caused by tmc-1 and eat-2 mutations in C. elegans by promoting metabolic remodeling and adaptation to the nutritional environment. [Read the Full Post]

Experimental and Theoretical Estimations of Atrazine's Adsorption in Mangosteen-Peel-Derived Nanoporous Carbons

78 views | Nov 06 2023

This study investigated the removal of atrazine using nanoporous carbons derived from mangosteen-peel chars, focusing on the role of nitrogen groups and surface chemistry, and elucidating the importance of micropores and mesopores in the adsorption process. [Read the Full Post]

VPS34-IN1 induces apoptosis of ER+ breast cancer cells via activating PERK/ATF4/CHOP pathway

0 views | Nov 06 2023

VPS34-IN1, a selective inhibitor of Class III Phosphatidylinositol 3-kinase (PI3K), exhibits an antitumor effect in estrogen receptor positive (ER+) breast cancer by activating the PERK/ATF4/CHOP pathway of endoplasmic reticulum (ER) stress, leading to apoptosis of breast cancer cells. [Read the Full Post]

Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis

71 views | Nov 06 2023

The MLX-Q139R mutation in the MLX gene plays a crucial role in the pathogenesis of Takayasu arteritis by promoting inflammasome formation, increased oxidative stress, and impaired autophagy. [Read the Full Post]

Acetaminophen impairs ferroptosis in the hippocampus of septic mice by regulating glutathione peroxidase 4 and ferroptosis suppressor protein 1 pathways

36 views | Nov 05 2023

Acetaminophen (APAP) inhibits neuronal ferroptosis in the hippocampal tissues of septic mice through the GPX4 and FSP1 pathways, leading to improved cognitive function and increased survival rate. [Read the Full Post]

Cordycepin inhibits myogenesis via activating the ERK1/2 MAPK signalling pathway in C2C12 cells

37 views | Nov 05 2023

Cordycepin inhibits myoblast differentiation by downregulating MyoD and MyoG, while preserving undifferentiated reserve cell pools through upregulation of Myf5 and p130, enhancing energy reserves, and activating ERK1/2 MAPK signaling, suggesting its potential for preventing and treating degenerative muscle diseases. [Read the Full Post]