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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Activation of Most Toll-Like Receptors in Whole Human Blood Attenuates Platelet Deposition on Collagen under Flow

130 views | Apr 11 2023

The study found that TLR signaling plays a complex role in platelet function under flow conditions and that the effects of TLR activation on platelet deposition depend on the specific TLR and its ligand, and that IKK and NF-κB inhibitors may be effective in inhibiting platelet deposition under flow. [Read the Full Post]

Targeting the Nerve Growth Factor Signaling Impairs the Proliferative and Migratory Phenotype of Triple-Negative Breast Cancer Cells

171 views | Apr 11 2023

The study investigates the role of nerve growth factor and its receptor, tropomyosin receptor kinase A, in triple-negative breast cancer and suggests that targeting TrkA may be a potential therapeutic strategy for this disease. [Read the Full Post]

A Cell System-Assisted Strategy for Evaluating the Natural Antioxidant-Induced Double-Stranded DNA Break (DSB) Style

149 views | Apr 11 2023

Researchers evaluated whether natural antioxidants induce DNA damage using gene-knockout cell lines and found that sulforaphane induces single-strand breaks or DNA strand crosslinks, quercetin induces double-strand breaks, while resveratrol exerts cytotoxic effects other than DNA damage, and the mechanisms through which kaempferol and genistein induce DNA damage remain unknown. [Read the Full Post]

Potentiation of ASIC currents by lysophosphatidic acid in rat dorsal root ganglion neurons

50 views | Apr 11 2023

LPA enhances ASIC-mediated electrophysiological activity and nociception via a LPA1 receptor and PKC signaling pathway, providing a novel peripheral mechanism underlying pain sensitization. [Read the Full Post]

Inhaled pirfenidone solution (AP01) for IPF: a randomised, open-label, dose-response trial

124 views | Apr 11 2023

The phase 1b trial evaluated the safety, tolerability, and efficacy of inhaled pirfenidone in patients with IPF and showed that the treatment was well-tolerated and may be a safe and effective alternative to oral pirfenidone or nintedanib. [Read the Full Post]

Investigation of gait, balance and lower extremity muscle activity during walking in patients with cervical spondylotic myelopathy using wearable sensors

88 views | Apr 10 2023

The study found that wearable sensors can detect changes in gait, balance, and lower extremity muscle activity in patients with CSM compared to age-matched healthy controls, suggesting potential for diagnosis and monitoring of CSM disease using wearable technology. [Read the Full Post]

miR-223 Plays a Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity

119 views | Apr 10 2023

The study found that exposure to the obesogen tributyltin (TBT) increased levels of the microRNA miR-223 in mesenchymal stem cells (MSCs), which may play a role in the development of obesity in male offspring of exposed pregnant mice through the PPARγ pathway. [Read the Full Post]

Interaction of copper potential metallodrugs with TMPRSS2: A comparative study of docking tools and its implications on COVID-19

62 views | Apr 10 2023

The research on Casiopeina-analogs as TMPRSS2 inhibitors and their interaction with the catalytic triad provides valuable insights into potential drug candidates for treating COVID-19. [Read the Full Post]

Endothelial Histone Deacetylase 1 Activity Impairs Kidney Microvascular NO Signaling in Rats fed a High Salt Diet

47 views | Apr 10 2023

The study found that a high salt diet impairs NO signaling in kidney microvascular endothelial cells through an HDAC1-dependent mechanism activated by a humoral factor called Plasma Derived Endothelial-dysfunction Mediator (PDEM). [Read the Full Post]

KL-FGF23-VD Axis in Improving Late-Onset Alzheimer's Disease by Modulating IKK/NF- κ B Signal Pathway

97 views | Apr 10 2023

The study suggests that the KL-FGF23-VD axis has potential therapeutic value for Alzheimer's disease treatment by regulating the IKK/NF-κB pathway. [Read the Full Post]

Neutralization of NET-associated human ARG1 enhances cancer immunotherapy

66 views | Apr 09 2023

The study investigates the role of neutrophil extracellular traps (NETs) and cathepsin S (CTSS) in regulating the activity of arginase 1 (ARG1) in pancreatic ductal adenocarcinoma (PDAC) and suggests the potential of targeting extracellular ARG1 with monoclonal antibodies as a therapeutic approach for PDAC in combination with immune checkpoint inhibitors. [Read the Full Post]

Omicron-induced interferon signalling prevents influenza A H1N1 and H5N1 virus infection

152 views | Apr 09 2023

Recent research shows that Omicron but not Delta induces a strong interferon response in primary human cells, protects cells from super-infection with influenza A viruses, and the response is mediated via MDA5 recognition of double-stranded RNA and involves the production of biologically active type I (α/β) and III (λ) interferons. [Read the Full Post]

Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy

121 views | Apr 09 2023

Oral baricitinib combined with NB-UVB phototherapy has shown to be a successful treatment option for refractory vitiligo by blocking the JAK-STAT pathway and stimulating melanocyte production. [Read the Full Post]

The cytotoxic activity of carfilzomib together with nelfinavir is superior to the bortezomib/nelfinavir combination in non-small cell lung carcinoma

117 views | Apr 09 2023

Combining carfilzomib with nelfinavir shows superior efficacy in inducing proteotoxicity and endoplasmic reticulum stress in non-small-cell-lung carcinoma (NSCLC) compared to the combination of bortezomib and nelfinavir, and may represent a future treatment option for NSCLC. [Read the Full Post]

The monoculture of cord-blood-derived CD34+ cells by an automated, membrane-based dynamic perfusion system with a novel cytokine cocktail

56 views | Apr 09 2023

The provided information describes an automated expansion protocol for cord blood-derived CD34+ cells, which can provide a sufficient number of T cell-depleted hematopoietic stem and progenitor cells for use in HLA-matched cord blood transplantation, with minimal residual lymphocytes. [Read the Full Post]

Inhibition of KIR2.1 decreases pulmonary artery smooth muscle cell proliferation and migration

64 views | Apr 08 2023

The study demonstrates that KIR2.1 regulates the TGF‑β1/SMAD2/3 signaling pathway and the expression of OPN and PCNA proteins, thereby regulating the proliferation and migration of PASMCs and participating in PVR, which could inform the development of effective therapeutic drugs for PH. [Read the Full Post]

HOW TO OPTIMALLY SEQUENCE AVAILABLE THERAPY LINES IN ADVANCED PROSTATE CANCER

65 views | Apr 08 2023

The optimal sequencing of available therapy lines for advanced prostate cancer should be individualized based on several factors and decided in collaboration with the patient and their healthcare team. [Read the Full Post]

Circulating small extracellular vesicles promote proliferation and migration of vascular smooth muscle cells via AXL and MerTK activation

69 views | Apr 08 2023

The study investigated the role of circulating small extracellular vesicles (csEVs) in vascular smooth muscle cell (VSMC) functions and neointima formation after vascular injury, demonstrating that csEVs enhance VSMC proliferation and migration via membrane phosphatidylserine (PS) and activate AXL and MerTK signaling pathways, and dual AXL/MerTK inhibition may be a potential treatment for vascular diseases. [Read the Full Post]

Integrated profiling uncovers prognostic, immunological, and pharmacogenomic features of ferroptosis in triple-negative breast cancer

59 views | Apr 08 2023

The study explores the role of ferroptosis in TNBC, identifying different patterns of ferroptosis associated with prognostic and immunological traits, proposing a ferroptosis-relevant scoring system, and predicting small-molecule agents for high-risk patients. [Read the Full Post]

Salmonella effector SopF regulates PANoptosis of intestinal epithelial cells to aggravate systemic infection

165 views | Apr 08 2023

The study demonstrates that SopF can attenuate intestinal inflammation and promote bacterial dissemination in mice infected with S. Typhimurium through a mechanism involving PDK1-RSK signaling that inhibits Caspase-8 activation and subverts PANoptosis. [Read the Full Post]