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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Long non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung cancer

151 views | May 25 2023

This passage describes a study on the role of lncRNA HIF1A-As2 in regulating the activation of KRAS in lung cancer and its potential as a therapeutic target. [Read the Full Post]

Targeting tumour-associated macrophages in hodgkin lymphoma using engineered extracellular matrix-mimicking cryogels

47 views | May 25 2023

The researchers used a biomimetic cryogel model to screen for invasion inhibitors and identified five drug hits, including ruxolitinib and PD-169316, which decreased tumor-associated macrophage invasion and modulated macrophage polarization in Hodgkin lymphoma. [Read the Full Post]

Combination of endothelial progenitor cells and BB-94 significantly alleviates brain damage in a mouse model of diabetic ischemic stroke

53 views | May 25 2023

EPCs and the matrix metalloproteinase inhibitor BB-94 may have protective effects against ischemic stroke by reducing the expression of MMPs, as demonstrated in both in vitro and in vivo experiments. [Read the Full Post]

Peptidoglycan from Bacillus anthracis Inhibits Human Macrophage Efferocytosis in Part by Reducing Cell Surface Expression of MERTK and TIM-3

61 views | May 25 2023

The study found that Bacillus anthracis peptidoglycan inhibits the capacity of human monocyte-derived macrophages to efferocytose apoptotic cells by reducing cell surface expression of efferocytic receptors, dependent on human serum opsonins and involving proteases. [Read the Full Post]

Metalloprotease domain latency protects ADAMTS13 against broad-spectrum inhibitors of metalloproteases while maintaining activity towards VWF

75 views | May 25 2023

The study found that the metalloprotease domain of ADAMTS13 protects it from inhibitors and exists in a latent state that is partially maintained by loops flanking the S1 and S1' specificity pockets. [Read the Full Post]

Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice

50 views | May 24 2023

USP7 may be a new therapeutic target for hypertrophic remodeling and heart failure due to its involvement in multiple signaling pathways that contribute to cardiac hypertrophy and remodeling. [Read the Full Post]

Patients with infective endocarditis undergoing cardiac surgery have distinct ROTEM profiles and more bleeding complications compared to patients without infective endocarditis

155 views | May 24 2023

This exploratory investigation found significantly altered coagulation profiles in patients with infective endocarditis, with concomitant hyper- and hypocoagulability, leading to increased bleeding complications and transfusion requirements, and suggests the need for adjustments to existing coagulation management algorithms in these high-risk patients. [Read the Full Post]

CFTR modulates aquaporin-mediated glycerol permeability in mouse Sertoli cells

68 views | May 24 2023

This study explores the potential molecular partnership between CFTR and AQPs in mouse Sertoli cells and suggests that the malfunction of CFTR and the consequent alteration in glycerol permeability is a potential link between male infertility and cystic fibrosis. [Read the Full Post]

Inhibitors of the Ubiquitin-Mediated Signaling Pathway Exhibit Broad-Spectrum Antiviral Activities against New World Alphaviruses

55 views | May 24 2023

The study investigated the use of small molecule inhibitors that interfere with UPS-associated signaling pathways as potential therapeutic candidates for treating mosquito-transmitted alphaviruses such as VEEV and EEEV, and found that three of them exhibited broad-spectrum antiviral activity against both viruses. [Read the Full Post]

ID3 mediates BMP2-induced downregulation of ICAM1 expression in human endometiral stromal cells and decidual cells

76 views | May 24 2023

This study highlights a potential molecular mechanism by which BMP2 regulates ICAM1 in the human endometrium, which could have therapeutic implications for unexplained recurrent pregnancy loss (uRPL). [Read the Full Post]

Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib

43 views | May 23 2023

The passage discusses the development and potency of type II RAF inhibitors, which are effective against RAF dimers and have clinical implications for various cancers, particularly in relation to the relative sparing of ARAF. [Read the Full Post]

Anti-tumor activity of the pan-RAF inhibitor TAK-580 in combination with KPT-330 (selinexor) in multiple myeloma

61 views | May 23 2023

The combination of the pan-RAF inhibitor TAK-580 and XPO1 inhibitor KPT-330 exhibits significant anti-tumor effects against multiple myeloma via the FOXO3a-Bim axis, suggesting that targeting multiple pathways simultaneously could be an effective strategy for treating MM. [Read the Full Post]

Renal tubular epithelial cells treated with calcium oxalate up-regulate S100A8 and S100A9 expression in M1-polarized macrophages via interleukin 6

78 views | May 23 2023

This study demonstrates that M1-polarized macrophages are the main source of S100A8 and S100A9 in the kidneys of nephrolithiasis patients, and that COM-induced IL6 secretion from renal tubular epithelial cells can up-regulate their expression in macrophages. [Read the Full Post]

A patent review of EZH2 inhibitors from 2017 and beyond

121 views | May 23 2023

EZH2 inhibitors are a promising class of drugs for the treatment of various diseases, particularly cancers, but further research is needed to optimize their efficacy and safety. [Read the Full Post]

Ubiquitin-Specific Proteases as Potential Therapeutic Targets in Bladder Cancer-In Vitro Evaluation of Degrasyn and PR-619 Activity Using Human and Canine Models

84 views | May 23 2023

The study found that Degrasyn showed greater anti-cancer activity against bladder cancer cell lines compared to the non-selective DUB inhibitor PR-619, inducing caspase-dependent apoptosis and triggering DNA damage. [Read the Full Post]

Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer

85 views | May 22 2023

This study found that combining ATR inhibitors, irradiation, and anti-PD-L1 therapy improved the efficacy of immunotherapy in colorectal cancer mouse models by promoting STING signaling and reinvigorating the tumor microenvironment. [Read the Full Post]

Antitumor efficacy of dual blockade with encorafenib plus cetuximab in combination with chemotherapy in human BRAFV600E mutant colorectal cancer

63 views | May 22 2023

The study suggests that a combination of cytotoxic chemotherapy and molecular targeted therapy is a promising therapeutic approach in the first-line treatment of BRAFV600E mCRC. [Read the Full Post]

FZD7, Regulated by Non-CpG Methylation, Plays an Important Role in Immature Porcine Sertoli Cell Proliferation

74 views | May 22 2023

This study explores the regulatory roles of non-CpG methylation in testicular development, identifying several hub genes such as FZD7, which is found to be important in linking the proliferation and apoptosis of Sertoli cells. [Read the Full Post]

The Protective Effect of Zebularine, an Inhibitor of DNA Methyltransferase, on Renal Tubulointerstitial Inflammation and Fibrosis

73 views | May 22 2023

Inhibiting DNA methylation can restore the balance between pro-inflammatory and anti-inflammatory pathways, alleviate renal inflammation and fibrosis, and highlight DNA methyltransferases as potential therapeutic targets for treating chronic kidney disease. [Read the Full Post]

Commiphora myrrha stimulates insulin secretion from β-cells through activation of atypical protein kinase C and mitogen-activated protein kinase

152 views | May 22 2023

The study investigated the molecular mechanism of action of Commiphora myrrha (CM)-induced insulin secretion and found that CM directly stimulates insulin secretion through activating known downstream effectors of insulin-stimulus secretion coupling, which is completely dependent on protein kinase activation, particularly the phosphorylation and activation of PKCζ and ERK1/2. [Read the Full Post]