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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Immunostimulatory effects of dairy probiotic strains Bifidobacterium animalis ssp. lactis HY8002 and Lactobacillus plantarum HY7717

104 views | Mar 14 2023

The study found that the combination of LAB strains HY8002 and HY7717 improved immune function in mice and has potential as an immunostimulant probiotic supplement for use in dairy foods. [Read the Full Post]

Management of antineutrophil cytoplasmic antibody-associated vasculitis: a changing tide

64 views | Mar 14 2023

Recent advances in the treatment of AAV have focused on reducing the toxicity of existing treatments and exploring newer treatments with better safety profiles, including targeted PLEX use, lower GC dosing, and increased rituximab use. [Read the Full Post]

Treating linear porokeratosis with topical lovastatin/cholesterol cream

125 views | Mar 14 2023

Linear porokeratosis is a rare skin condition characterized by unilateral linear lesions that follow the lines of Blaschko and is currently treated with therapies aimed at restoring the mevalonate biosynthesis pathway and keratinocyte cholesterol availability, such as compounded 2% lovastatin/2% cholesterol cream. [Read the Full Post]

Lorazepam in catatonia - Past, present and future of a clinical success story

106 views | Mar 14 2023

This passage discusses the history, effectiveness, and potential future directions for the use of lorazepam in the treatment of catatonia, emphasizing the importance of empirical observation and clinical practice, while also calling for further scientific investigation. [Read the Full Post]

Prophylactic Agents for Preventing Cardiotoxicity Induced Following Anticancer Agents: A Systematic Review and Meta-Analysis of Clinical Trials

112 views | Mar 14 2023

This meta-analysis showed that prophylactic treatment with cardio-protective drugs can protect the left ventricular ejection fraction (LVEF) and prevent EF drop in patients undergoing chemotherapy with anthracyclines. [Read the Full Post]

In silico prediction of potential inhibitors for SARS-CoV-2 Omicron variant using molecular docking and dynamics simulation-based drug repurposing

55 views | Mar 13 2023

The study aimed to identify potential drugs against Omicron by testing previously repurposed anti-COVID-19 drugs, and raltegravir and hesperidin were found to have high binding affinities and stabilities to Omicron and may be potential drugs, but further clinical studies are needed to confirm their efficacy and safety. [Read the Full Post]

Attenuation of initial pilocarpine-induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of the extracellular taurine in the hippocampus

47 views | Mar 13 2023

The study showed that the beneficial effect of MSO in mitigating the intensity of initial pilocarpine-induced seizures in juvenile rats is due to the prevention of cell volume increase concurrent with the onset of seizures, as indicated by the strong correlation between the attenuation of seizures and extracellular accumulation of taurine. [Read the Full Post]

HDAC8-Selective Inhibition by PCI-34051 Enhances the Anticancer Effects of ACY-241 in Ovarian Cancer Cells

139 views | Mar 13 2023

The study suggests that co-inhibition of HDAC6 and HDAC8 through selective inhibitors could be a novel therapeutic approach for ovarian cancer patients with wild-type p53. [Read the Full Post]

Pharmacokinetic and Pharmacodynamic Comparison of Fluticasone Propionate/Formoterol Fumarate Administered via a Pressurized Metered-Dose Inhaler and a Novel Breath-Actuated Inhaler in Healthy Volunteers

93 views | Mar 13 2023

The passage describes the results of two studies comparing the exposure of fluticasone/formoterol following administration via BAI with pMDI with/without a spacer in healthy volunteers, which showed that BAI performance was comparable to pMDI and systemic safety with BAI was no worse than the primary comparator. [Read the Full Post]

A new series of hydrazones as small-molecule aldose reductase inhibitors

106 views | Mar 13 2023

The study reports the design, synthesis, and evaluation of tetrazole-hydrazone hybrids as aldose reductase inhibitors, identifying compound 4 as the most potent and safe inhibitor for further in vivo studies. [Read the Full Post]

Effect of Pre-Meal Metformin With or Without an Acute Exercise Bout on Postprandial Lipemic and Glycemic Responses in Metabolic Syndrome Patients: A Randomized, Open Label, Crossover Study

237 views | Mar 12 2023

Pre-meal metformin administration 30 minutes prior to the meal has favorable effects on postprandial total cholesterol and LDL-cholesterol levels compared to its administration with the meal, and the addition of one exercise bout only improves postprandial glycemia and insulinemia in metabolic syndrome patients. [Read the Full Post]

Loss of TRPV4 Cation Channel Inhibition of Macrophage Infiltration and Neovascularization in a Mouse Cornea

129 views | Mar 12 2023

This study shows that TRPV4 plays a role in injury-induced neovascularization in the corneal stroma and may be a potential therapeutic target to prevent unfavorable neovascularization post-injury. [Read the Full Post]

Effects of supplementing organic- and inorganic-based selenium with vitamin E on intestinal histomorphology, caecal bacterial proliferation, and short-chain fatty acid profile in layer hens

167 views | Mar 12 2023

Organic selenium supplementation, particularly bacterial organic selenium, enhances intestinal histomorphology, increases beneficial caecal bacterial proliferation, and increases butyric acid content in layer chickens. [Read the Full Post]

Multivariate Chemometric Comparison of Forced Degradation and Electrochemical Oxidation LC-MS Profiles of Maraviroc

136 views | Mar 12 2023

The study found that maraviroc is susceptible to UVA, H2O2, and electrochemical degradation, and suggests that electrochemical methods can be used as a supplement to forced degradation procedures for a quicker and relatively low-cost alternative. [Read the Full Post]

TGFβ1+CCR5+ neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice

129 views | Mar 12 2023

The study suggests that reducing the numbers of TGFβ1+CCR5+ neutrophils in the bone marrow, potentially through the use of a CCR5 antagonist like maraviroc, could be a treatment for age-related osteoporosis. [Read the Full Post]

Electrochemically assisted production of biogenic palladium nanoparticles for the catalytic removal of micropollutants in wastewater treatment plants effluent

86 views | Mar 11 2023

This work demonstrates the potential of biogenic palladium nanoparticles to remove persistent micropollutants from wastewater, with the size of the nanoparticles affecting their catalytic activity. [Read the Full Post]

Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms

123 views | Mar 11 2023

The study demonstrates the potential clinical utility of OligoG in conjunction with nystatin against Candida spp. in the prevention and topical treatment of candidal biofilm infections. [Read the Full Post]

Surface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteins

90 views | Mar 11 2023

The research proposes using metal-organic frameworks (MOFs) functionalized with repurposed antiviral agents to selectively bind and deactivate respiratory coronaviruses, highlighting their potential in combating future pandemics. [Read the Full Post]

Effects of extended oral antibiotic prophylaxis on surgical site infections after instrumented spinal fusion: a cohort study of 901 patients with a minimum follow-up of 1 year

63 views | Mar 11 2023

Extended antibiotic prophylaxis is associated with a lower incidence of superficial surgical site infection in instrumented spine surgery. [Read the Full Post]

Chitosan-Enclosed Menadione Sodium Bisulfite as an Environmentally Friendly Alternative to Enhance Biostimulant Properties against Drought

107 views | Mar 11 2023

The use of nanoencapsulation to deliver menadione sodium bisulfite has been shown to improve its protective properties against water deficit stress and reduce the need for continuous retreatment, highlighting the potential of nanotechnology to enhance the performance of biostimulants in agriculture. [Read the Full Post]