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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

A new CCCH-type zinc finger-related lncRNA signature predicts the prognosis of clear cell renal cell carcinoma patients

31 views | Sep 30 2023

The study constructed a prognostic signature based on eight CCCH-type zinc finger-associated lncRNAs (CTZFLs) that independently predicted patient prognosis and showed potential for aiding in medication selection for clear cell renal cell carcinoma (ccRCC). [Read the Full Post]

Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL)

57 views | Sep 30 2023

This review examines the recent advancements in the treatment of relapsed/refractory chronic lymphocytic leukemia (CLL), including targeted therapies, chimeric antigen receptor (CAR) T cell therapy, and the role of measurable residual disease (MRD) assessment, providing insights into therapeutic options and considerations for individualized treatment selection. [Read the Full Post]

Aryl hydrocarbon receptor is regulated via multiple mechanisms in human keratinocytes

47 views | Sep 30 2023

The study reveals that the Aryl hydrocarbon receptor (AhR) is primarily regulated through proteasomal degradation, ligand-induced and ARNT-dependent mechanisms, as well as transcriptional regulation by HDACs, indicating a complex system for controlling AhR expression and protein stability in epidermal keratinocytes. [Read the Full Post]

KRASG12C mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer

95 views | Sep 30 2023

The study reveals that the KRAS-TOPK axis contributes to the progression of non-small cell lung cancer (NSCLC) with the KRASG12C mutation, and targeting this axis could enhance the anticancer effects of existing chemotherapeutics. [Read the Full Post]

African swine fever virus pS273R antagonizes stress granule formation by cleaving the nucleating protein G3BP1 to facilitate viral replication

75 views | Sep 30 2023

The study reveals that African swine fever virus (ASFV) inhibits the formation of cytoplasmic stress granules (SGs) by cleaving the G3BP1 protein, thereby evading host stress and innate antiviral responses. [Read the Full Post]

Real-World Treatment Outcomes of MET Exon14 Skipping in Non-small Cell Lung Cancer: GFPC 03-18 Study

66 views | Sep 29 2023

The real-life study found no evidence of a survival benefit with anti-MET tyrosine kinase inhibitors (TKIs) in patients with advanced non-small cell lung cancer (aNSCLC) and MET exon14 skipping mutations (METexon14). [Read the Full Post]

Design of OSMI-4 Analogs Using Scaffold Hopping: Investigating the Importance of the Uridine Mimic in the Binding of OGT Inhibitors

77 views | Sep 29 2023

This study introduces a modified peptide part of OSMI-4 and incorporates new sulfonamide UDP mimics to design and evaluate a small library of OSMI-4 derivatives, providing insights into the OGT binding pocket and its specificity towards quinolone-4-carboxamides. [Read the Full Post]

ATF4 renders human T-cell acute lymphoblastic leukemia cell resistance to FGFR1 inhibitors through amino acid metabolic reprogramming

57 views | Sep 29 2023

This study demonstrates that targeting FGFR1 in human T-cell acute lymphoblastic leukemia (T-ALL) is a potential therapeutic strategy, but the development of resistance to FGFR1 inhibitors is mediated by ATF4-mediated amino acid metabolic reprogramming, which can be overcome by synergistically inhibiting FGFR1 and mTOR. [Read the Full Post]

BRD9 is an essential regulator of glycolysis that creates an epigenetic vulnerability in colon adenocarcinoma

67 views | Sep 29 2023

The study revealed that BRD9 plays important roles in colon cancer metabolism and tumor progression, highlighting its potential as a valuable therapeutic target for patients with colon cancer (COAD). [Read the Full Post]

Bone impact after two years of low-dose oral contraceptive use during adolescence

184 views | Sep 29 2023

The present study indicates that the use of combined hormonal contraceptives in healthy adolescents is associated with compromised bone mass acquisition, with a more pronounced negative impact observed in those using contraceptives containing 30 μg of Ethinylestradiol. [Read the Full Post]

α-Synuclein induces Th17 differentiation and impairs the function and stability of Tregs by promoting RORC transcription in Parkinson's disease

31 views | Sep 28 2023

Alpha-synuclein promotes the imbalance between regulatory T cells and Th17 cells in Parkinson's disease by upregulating the transcription of retinoid-related orphan nuclear receptor γt, leading to impaired Treg stability and increased Th17 differentiation. [Read the Full Post]

Pharmacological blockade of TEAD-YAP reveals its therapeutic limitation in cancer cells

57 views | Sep 28 2023

Targeting TEAD autopalmitoylation in YAP-dependent cancers shows promise as a therapeutic approach, but the transient cell cycle inhibition and the activation of the VGLL3-mediated SOX4/PI3K/AKT signaling axis present limitations that can be overcome through combination therapy with TEAD and AKT inhibitors. [Read the Full Post]

TXNIP Suppresses the Osteochondrogenic Switch of Vascular Smooth Muscle Cells in Atherosclerosis

90 views | Sep 28 2023

TXNIP is identified as a novel regulator of atherosclerotic calcification by suppressing bone morphogenetic protein signaling and inhibiting the phenotypic transition of vascular smooth muscle cells towards an osteochondrogenic phenotype. [Read the Full Post]

Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein

109 views | Sep 28 2023

This study identified fibroblast activation protein (FAP) and dipeptidyl peptidase-4 (DPP4) as proteases responsible for cleaving the cellular prion protein (PrPC), with their activity and modulation affecting the physiology and pathogenic potential of PrPC and its associated diseases. [Read the Full Post]

Pancreas Preservation with a Neutrophil Elastase Inhibitor, Alvelestat, Contributes to Improvement of Porcine Islet Isolation and Transplantation

44 views | Sep 28 2023

The study demonstrated that pancreatic preservation with alvelestat, a neutrophil elastase inhibitor, improved the yield and function of porcine islets, suggesting its potential as a novel clinical strategy for enhancing the outcome of islet transplantation. [Read the Full Post]

ERK inhibitor ASN007 effectively overcomes acquired resistance to EGFR inhibitor in non-small cell lung cancer

76 views | Sep 27 2023

The study demonstrates that targeting the ERK signaling pathway with the selective inhibitor ASN007 in combination with EGFR TKIs holds promise for overcoming acquired resistance and inhibiting tumor growth in EGFR-mutated non-small cell lung cancer (NSCLC) patients. [Read the Full Post]

Diazoxide improves muscle function in association with improved dyslipidemia and decreased muscle oxidative stress in streptozotocin-induced diabetic rats

85 views | Sep 27 2023

Diazoxide administration in diabetic rats improves muscle strength development, reduces fatigue, lowers cholesterol and triglyceride levels, and improves oxidative stress parameters, suggesting its potential as a therapeutic intervention for diabetes-related complications. [Read the Full Post]

RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer

203 views | Sep 27 2023

RNF112 suppresses gastric cancer progression by directly ubiquitinating FOXM1, making the RNF112/FOXM1 axis a potential prognostic biomarker and therapeutic target in gastric cancer. [Read the Full Post]

Effectiveness of netarsudil 0.02% in lowering intraocular pressure in patients with secondary glaucoma

181 views | Sep 27 2023

Netarsudil, 0.02%, was found to effectively lower intraocular pressure in patients with secondary forms of glaucoma, particularly uveitic glaucoma, based on a retrospective study. [Read the Full Post]

Thalidomide derivatives as nanomolar human neutrophil elastase inhibitors: Rational design, synthesis, antiproliferative activity and mechanism of action

90 views | Sep 27 2023

Through rational design, a series of thalidomide-derived compounds were synthesized, and compound 4f demonstrated strong inhibition of human neutrophil elastase (HNE), comparable to sivelestat, and exhibited enhanced antiproliferative activity against various cancer cell lines, inducing cell cycle arrest and apoptosis in T47D breast carcinoma cells. [Read the Full Post]