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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

BRD4: New hope in the battle against glioblastoma

56 views | Jul 28 2023

This review provides a comprehensive overview of the roles and mechanisms of BRD4 in glioblastoma pathogenesis, as well as evaluates the potential of BRD4 inhibitors and degraders as novel treatment strategies against GBM. [Read the Full Post]

Mitochondrial impairment and downregulation of Drp1 phosphorylation underlie the antiproliferative and proapoptotic effects of alantolactone on oral squamous cell carcinoma cells

82 views | Jul 28 2023

The study found that alantolactone (ALT) inhibited the proliferation and promoted apoptosis of oral squamous cell carcinoma (OSCC) cells by disrupting mitochondrial homeostasis and regulating dynamin-related protein 1 (Drp1), suggesting its potential as a therapeutic candidate for OSCC. [Read the Full Post]

Anal Cancer Prevention Through the Topical Use of Single or Dual PI3K/mTOR Inhibitors

108 views | Jul 28 2023

In this study, topical inhibition of the mTOR and/or PI3K pathways demonstrated promising results in increasing tumor-free survival and reducing squamous cell carcinoma in mice with anal dysplasia and anal cancer. [Read the Full Post]

Novel therapeutic approaches for pleural mesothelioma identified by functional ex vivo drug sensitivity testing

73 views | Jul 28 2023

The study found that mTOR and Chk1 pathway inhibitors showed promising efficacy in established and patient-derived cell models of pleural mesothelioma, suggesting their potential as novel treatment strategies. [Read the Full Post]

Timely expression of PGAM5 and its cleavage control mitochondrial homeostasis during neurite re-growth after traumatic brain injury

101 views | Jul 27 2023

The study reveals that phosphoglycerate mutase 5 (PGAM5) acts as a mitochondrial sensor in traumatic brain injury (TBI), promoting mitophagy and subsequent cleavage by PARL, leading to increased mitochondrial transcription factor A (TFAM) expression and functional recovery. [Read the Full Post]

pH-sensitive smart indicators based on cellulose and different natural pigments for tracing kimchi ripening stages

333 views | Jul 27 2023

The study found that cellulose-based pH-sensitive indicators loaded with natural pigments showed more pronounced color changes in response to lactic acid and pH variations, with alkalized indicators being particularly effective for monitoring the fermentation process of acidic foods such as kimchi. [Read the Full Post]

Visfatin-induced upregulation of lipogenesis via EGFR/AKT/GSK3β pathway promotes breast cancer cell growth

53 views | Jul 27 2023

Visfatin induces lipid synthesis and accumulation in breast cancer cells through activation of the EGFR/AKT/GSK3β pathway, promoting cell survival and proliferation. [Read the Full Post]

LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition

46 views | Jul 27 2023

The study demonstrates that high expression of SREBP2 in hepatocellular carcinoma (HCC) is associated with poor prognosis and promotes HCC cell invasion and metastasis through the epithelial-mesenchymal transition (EMT) process, suggesting SREBP2 as a potential therapeutic target for HCC. [Read the Full Post]

The Combination of Sinusoidal Perfusion Enhancement and Apoptosis Inhibition by Riociguat Plus a Galactose-PEGylated Bilirubin Multiplexing Nanomedicine Ameliorates Liver Fibrosis Progression

107 views | Jul 27 2023

The study describes a novel strategy for treating liver fibrosis by combining sinusoidal perfusion enhancement with apoptosis inhibition using riociguat and a hepatocyte-targeting galactose-PEGylated bilirubin nanomedicine (Sel@GBRNPs). [Read the Full Post]

Beyond Weight Loss: Added Benefits Could Guide the Choice of Anti-Obesity Medications

86 views | Jul 26 2023

This comprehensive review explores the added benefits and drawbacks of approved and upcoming centrally-acting anti-obesity drugs, highlighting their potential for personalized, pharmacological management of obesity and its associated complications. [Read the Full Post]

A high-concentrate diet induces inflammatory injury via regulating Ca2+/CaMKKβ-mediated autophagy in mammary gland tissue of dairy cows

108 views | Jul 26 2023

The study found that a high-concentrate diet induced autophagy in mammary gland tissue through the Ca2+/CaMKKβ-AMPK signaling pathway, leading to inflammatory injury in dairy cows. [Read the Full Post]

MAPK-interacting kinases inhibition by eFT508 overcomes chemoresistance in preclinical model of osteosarcoma

274 views | Jul 26 2023

The study highlights the therapeutic potential of eFT508, a selective inhibitor of MNK1/2, alone and in combination with paclitaxel, as a promising treatment for osteosarcoma by inhibiting tumor growth and demonstrating selectivity and synergistic effects. [Read the Full Post]

Treatment with eFT-508 increases chemosensitivity in breast cancer cells by modulating the tumor microenvironment

212 views | Jul 26 2023

Tomivosertib (eFT-508) demonstrates promising efficacy both in vitro and in vivo, including synergistic effects with adriamycin, suggesting its potential as a more efficacious therapeutic option for patients with triple-negative breast cancer (TNBC). [Read the Full Post]

The mRNA-binding protein DDX3 mediates TGF-β1 upregulation of translation and promotes pulmonary fibrosis

85 views | Jul 25 2023

Inhibiting the mRNA-binding protein DDX3, which mediates TGF-β1 upregulation of translation, shows promise in reducing pulmonary fibrosis and associated inflammation in experimental models. [Read the Full Post]

Microglial and Neuronal Cell Pyroptosis Induced by Oxygen-Glucose Deprivation/Reoxygenation Aggravates Cell Injury via Activation of the Caspase-1/GSDMD Signaling Pathway

67 views | Jul 25 2023

This study demonstrates that oxygen-glucose deprivation/reoxygenation (OGD/R) induces pyroptosis in microglial and neuronal cells, aggravates cell injury via caspase-1/GSDMD signaling pathway, and suggests caspase-1 and GSDMD as potential therapeutic targets for cerebral ischemia/reperfusion. [Read the Full Post]

Checkpoint kinase‑1 inhibition and etoposide exhibit a strong synergistic anticancer effect on chronic myeloid leukemia cell line K562 by impairing homologous recombination DNA damage repair

95 views | Jul 25 2023

In summary, the study demonstrates that silencing CHK1 or inhibiting its activity, in combination with chemotherapy, shows promise as an effective strategy for enhancing the cytotoxic effects and overcoming chemotherapeutic resistance in chronic myeloid leukemia (CML). [Read the Full Post]

Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis

58 views | Jul 25 2023

Simultaneous inhibition of NRF2 and GPX4 shows promise as a synergistic combination therapy targeting ferroptosis and overcoming drug resistance in acute myeloid leukemia (AML). [Read the Full Post]

Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial

55 views | Jul 25 2023

The Glycemia Reduction Approaches in Diabetes (GRADE) trial found no significant differences in kidney outcomes when comparing the addition of different glucose-lowering medications to metformin for glycemic management in individuals with type 2 diabetes. [Read the Full Post]

Inhibition of LAR attenuates neuroinflammation through RhoA/IRS-1/Akt signaling pathway after intracerebral hemorrhage in mice

80 views | Jul 24 2023

This study revealed that leukocyte common antigen-related phosphatase (LAR) contributes to neuroinflammation after intracerebral hemorrhage (ICH) via the RhoA/IRS-1 pathway, and the administration of an extracellular LAR peptide (ELP) may serve as a potential therapeutic strategy to attenuate LAR-mediated neuroinflammation following ICH. [Read the Full Post]

A narrative review from gut to lungs: non-small cell lung cancer and the gastrointestinal microbiome

177 views | Jul 24 2023

The gut microbiome plays a crucial role in modulating the immune response and therapeutic outcomes in lung cancer, highlighting the potential for microbiome-based interventions to improve treatment efficacy. [Read the Full Post]