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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice

45 views | May 21 2023

Coronarin A, a natural compound isolated from Hedychium gardnerianum, has potential therapeutic effects in the treatment of type 2 diabetes mellitus by stimulating glycogen synthesis and suppressing gluconeogenesis via activation of the PI3K/Akt/GSK3β and ERK/Wnt/β-catenin pathways and inhibition of mTORC1/S6K1 signaling. [Read the Full Post]

MiR-139 Affects Radioresistance in Esophageal Cancer by Targeting the PDK1/AKT/Cyclin D1 Signaling Pathway

43 views | May 21 2023

MiR-139 enhances radiosensitivity in esophageal cancer by regulating the cell cycle through the PDK1/Akt/Cyclin D1 signaling pathway, according to a study using KYSE150R cells and clinical data from 110 EC patients. [Read the Full Post]

Apoptosis or Antiapoptosis? Interrupted Regulated Cell Death of Host Cells by Ascovirus Infection In Vitro

37 views | May 21 2023

This study investigates the antiapoptotic capacity of ascovirus-infected insect cells and their biochemical characteristics during different stages of infection. [Read the Full Post]

Functional Assessment of Kinesin-7 CENP-E in Spermatocytes using In Vivo Inhibition, Immunofluorescence and Flow Cytometry

0 views | May 21 2023

The article describes a practical and efficient in vivo inhibition method for kinesin-7 CENP-E in mouse spermatocytes via testicular injection, facilitating mechanistic studies of meiosis and potential clinical applications. [Read the Full Post]

Solubilization, purification, and ligand binding characterization of G protein-coupled receptor SMO in native membrane bilayer using styrene maleic acid copolymer

97 views | May 21 2023

The study demonstrates the use of SMA-nanodiscs to solubilize and purify the SMO transmembrane domain in a native-like lipid environment for investigating the structure, function, and drug development of SMO proteins. [Read the Full Post]

Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation

117 views | May 20 2023

Small molecule compounds promoting hepatocyte dedifferentiation may facilitate the growth of transplanted hepatocytes in vivo and improve the efficacy of hepatocyte therapy for end-stage liver disease. [Read the Full Post]

JMJD3 Promotes Myeloid Fibroblast Activation and Macrophage Polarization in Kidney Fibrosis

122 views | May 20 2023

This study demonstrates that JMJD3 plays a crucial role in myeloid fibroblast activation, macrophage polarization, and renal fibrosis development, making it a potential therapeutic target for chronic kidney disease. [Read the Full Post]

Administration of an LXR agonist promotes atherosclerotic lesion remodelling in murine inflammatory arthritis

104 views | May 20 2023

The study shows that the LXR agonist T0901317 improves cholesterol efflux and atherosclerotic lesion regression in murine arthritis, potentially offering therapeutic benefits for patients with rheumatoid arthritis and atherosclerotic cardiovascular disease. [Read the Full Post]

DOT1L promotes cell proliferation and invasion by epigenetically regulating STAT5B in renal cell carcinoma

63 views | May 20 2023

Targeting DOT1L may be a potential therapeutic intervention for renal cell carcinoma as it promotes RCC progression by epigenetically promoting STAT5B transcription in a histone methyltransferase-dependent manner. [Read the Full Post]

Tyrosine Kinase Inhibitors Target B Lymphocytes

243 views | May 20 2023

Protein kinase inhibitors previously used to treat ALK-positive lung cancer cells have shown potential in targeting LTK-positive B cells, providing new treatment options for autoimmune disorders and blood cancers. [Read the Full Post]

Recommendations on the use of azole antifungals in hematology-oncology patients

35 views | May 19 2023

The administration of antifungal drugs in patients receiving hematology-oncology treatment requires careful monitoring and dose adjustments to minimize the risk of drug interactions and potential complications with certain antineoplastic drugs. [Read the Full Post]

Smoking-related epigenetic modifications are associated with the prognosis and chemotherapeutics of patients with bladder cancer

74 views | May 19 2023

The study identified smoking-related epigenetic modifications in bladder cancer and constructed a corresponding prognostic model, which was linked to different sensitivities to chemotherapeutics. [Read the Full Post]

Kv1.3 blockade by ShK186 modulates CD4+ effector memory T-cell activity of patients with Granulomatosis with polyangiitis

156 views | May 19 2023

The study suggests that Kv1.3 blockade using ShK-186 may be a potential treatment strategy for GPA by modulating the activity of CD4+TEM cells and reducing the production of pro-inflammatory cytokines, with less harmful side effects than current immunosuppressive regimens. [Read the Full Post]

Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates

169 views | May 19 2023

The study provides preliminary evidence that the combination therapy with MET and FGFR inhibitors is a safe and biologically active treatment option for patients with relapsed/refractory acute myeloid leukemia. [Read the Full Post]

Eradication of Mycobacterium abscessus infection in cystic fibrosis with initiation of Elexacaftor/Tezacaftor/Ivacaftor

59 views | May 19 2023

This case highlights the potential positive impact of ETI, a CFTR modulator combination, on the treatment of challenging infections such as M. abscessus in CF. [Read the Full Post]

Structural, spectroscopic, luminescence sensing and TD-DFT theoretical studies of a CuP2N-type complex

130 views | May 18 2023

The passage describes a heteroleptic cuprous complex with a CuP2N coordination triangle, which exhibits UV-Vis absorption due to LLCT characteristic excited states and luminescence light-up sensing for pyridine in a paper-based film. [Read the Full Post]

Celastrol inhibits necroptosis by attenuating the RIPK1/RIPK3/MLKL pathway and confers protection against acute pancreatitis in mice

159 views | May 18 2023

Celastrol has been found to inhibit necroptosis by attenuating the phosphorylation of RIPK1, RIPK3, and MLKL and mitochondrial dysfunction in in vitro models, and in a mouse model of acute pancreatitis, it significantly reduced the severity of the disease and decreased the phosphorylation of MLKL in pancreatic tissues. [Read the Full Post]

SMAC Mimetics Synergistically Cooperate with HDAC Inhibitors Enhancing TNF-α Autocrine Signaling

72 views | May 18 2023

The combination of SMAC mimetics and HDAC inhibitors shows remarkable synergy in suppressing IAP proteins and restoring apoptotic pathways, providing a potential therapeutic strategy for recurrent ovarian cancer. [Read the Full Post]

PYCR1 promotes the malignant progression of lung cancer through the JAK-STAT3 signaling pathway via PRODH-dependent glutamine synthesize

125 views | May 18 2023

PYCR1 has clinical significance in the diagnosis and prognosis of lung cancer, and its pro-tumorigenic role in lung cancer may be attributed to its regulation of the JAK-STAT3 signaling pathway and the metabolism link between proline and glutamine. [Read the Full Post]

Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model

35 views | May 18 2023

The study demonstrates the essential roles of PI3K-δ and PI3K-γ in CLL and supports the use of duvelisib as a potential therapeutic intervention, including for patients who are resistant to BTKi therapy. [Read the Full Post]