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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Blog of Signaling Pathways

Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development

69 views | Jun 10 2023

ENO2 plays a crucial role in head and neck squamous cell carcinoma (HNSCC) by promoting cell proliferation and glycolysis through regulation of PKM2 stability and nuclear translocation, and targeting ENO2 shows potential as a therapeutic strategy for HNSCC treatment. [Read the Full Post]

Icariin promotes osteogenic differentiation by upregulating alpha-enolase expression

33 views | Jun 10 2023

Icariin promotes osteogenic differentiation by upregulating alpha-enolase (Eno1) and activating the BMP/Smad4 signaling pathway, indicating Eno1 as a promising drug target for regulating bone formation. [Read the Full Post]

Stabilization of the Quadruplex-Forming G-Rich Sequences in the Rhinovirus Genome Inhibits Uncoating-Role of Na+ and K

46 views | Jun 10 2023

This research investigated the potential of G-quadruplex structures in inhibiting the replication cycle of rhinoviruses, with GQ-stabilizing compounds interfering with viral uncoating and promoting the formation and/or stabilization of GQs, impairing RNA unraveling and release from the virion. [Read the Full Post]

A unique 7p/12q chromosomal abnormality associated with recurrent abortion and hypofibrinogenemia

64 views | Jun 10 2023

Recurrent first-trimester abortions in a 25-year-old woman with hypofibrinogenemia and a unique chromosomal abnormality (t(7;12)) suggest a potential relationship between the two conditions, while successful gestation following fibrinogen infusion indicates the critical role of fibrinogen concentration in securing implantation [Read the Full Post]

Glycolytic System in Axons Supplement Decreased ATP Levels after Axotomy of the Peripheral Nerve

57 views | Jun 10 2023

The study demonstrates that the glycolytic system in both Schwann cells and axons is the main source of ATP maintenance in the distal nerve stump during Wallerian degeneration, highlighting its significance in neurologic therapies. [Read the Full Post]

IL-33/ST2 antagonizes STING signal transduction via autophagy in response to acetaminophen-mediated toxicological immunity

116 views | Jun 09 2023

This study investigates the role of IL-33/ST2 signaling in regulating APAP-induced STING signaling and suggests that inhibiting cGAS/STING may be a potential therapy for AILI. [Read the Full Post]

OONO-/MMP2/MMP9 pathway-mediated apoptosis of porcine granulosa cells is associated with DNA damage

92 views | Jun 09 2023

The passage describes a new mechanism for porcine follicular atresia involving peroxynitrite anion, which can increase the expression of matrix metalloproteinase 2 and 9, resulting in DNA damage, inhibition of DNA repair and apoptosis of granulosa cells. [Read the Full Post]

S-1-propenyl-L-cysteine suppresses lipopolysaccharide-induced expression of matrix metalloproteinase-1 through inhibition of tumor necrosis factor-α converting enzyme-epidermal growth factor receptor axis in human gingival fibroblasts

68 views | Jun 09 2023

S-1-propenyl-L-cysteine, a sulfur bioactive compound found in aged garlic extract, suppresses the expression of matrix metalloproteinase-1 through inhibition of the tumor necrosis factor-α converting enzyme-epidermal growth factor receptor axis in gingival fibroblasts, suggesting it may be an effective therapeutic agent for periodontal disease. [Read the Full Post]

Toxic hepatitis in metastatic breast cancer patient using ribociclib and denosumab

47 views | Jun 09 2023

Denosumab-induced hepatotoxicity is a rare occurrence, as reported in a limited number of cases, and in the case described, liver values improved after discontinuation of denosumab. [Read the Full Post]

Inhibitors of the Oncogenic PA2G4-MYCN Protein-Protein Interface

150 views | Jun 09 2023

The discovery of WS6 analogues that inhibit the PA2G4-MYCN interaction represents a promising breakthrough in neuroblastoma treatment and potentially other MYCN-driven cancers, with reduced toxicity towards normal cells. [Read the Full Post]

Galectin-1, a novel promising target for outcome prediction and treatment in SCLC

47 views | Jun 08 2023

This study suggests that Gal-1 may serve as a prognostic biomarker and therapeutic target in small-cell lung cancer based on its correlation with poor overall survival and the significant reduction in tumor size observed with Gal-1 inhibition in a SCLC-PDX model. [Read the Full Post]

Apigenin Alleviated High-Fat-Diet-Induced Hepatic Pyroptosis by Mitophagy-ROS-CTSB-NLRP3 Pathway in Mice and AML12 Cells

86 views | Jun 08 2023

This passage describes a study on the effects of apigenin on liver injury caused by a high-fat diet and palmitic acid-induced pyroptosis in liver cells through the mitophagy-ROS-CTSB-NLRP3 pathway. [Read the Full Post]

Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B

134 views | Jun 08 2023

The study investigated the pH-dependent inhibitory properties of CA-074, a selective inhibitor of cathepsin B, and found it to be more effective at inhibiting cathepsin B at an acidic pH of 4.6 with nM potency, while maintaining its specificity for cathepsin B over other cysteine cathepsins under both acidic and neutral pH conditions. [Read the Full Post]

Late sodium current in synergism with Ca2+/calmodulin-dependent protein kinase II contributes to β-adrenergic activation-induced atrial fibrillation

139 views | Jun 08 2023

Late INa and CaMKII play important roles in β-adrenergic stimulation-induced atrial fibrillation, and the inhibition of both can exert synergistic anti-arrhythmic effects. [Read the Full Post]

Characterization of Plasmodium falciparum prohibitins as novel targets to block infection in humans by impairing the growth and transmission of the parasite

217 views | Jun 08 2023

The study characterizes Plasmodium falciparum prohibitins (PHBs), showing their expression in both asexual and sexual blood stages and localization in mitochondria, and demonstrating their involvement in stabilizing mitochondrial DNA and maintaining integrity, with potential druggability for blocking parasite growth using Rocaglamide (Roc-A). [Read the Full Post]

DEEMD: Drug Efficacy Estimation Against SARS-CoV-2 Based on Cell Morphology With Deep Multiple Instance Learning

91 views | Jun 07 2023

DEEMD is a computational pipeline using deep neural network models within a multiple instance learning framework to identify putative treatments effective against SARS-CoV-2 based on morphological analysis of the RxRx19a dataset. [Read the Full Post]

Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway

129 views | Jun 07 2023

AS-IV can inhibit hypoxia-induced oxidative stress and apoptosis in hippocampal neurons by downregulating the calpain-1/HIF-1α/caspase-3 pathway. [Read the Full Post]

Systemic treatment in patients with Child-Pugh B liver dysfunction and advanced hepatocellular carcinoma

161 views | Jun 07 2023

Hepatocellular carcinoma (HCC) is a major cause of death among patients with liver cirrhosis, and the limited efficacy of available therapies in patients with moderate liver dysfunction highlights the need for improved treatment algorithms and novel therapies specifically designed for this patient population. [Read the Full Post]

Anisomycin inhibits Coxsackievirus B replication by promoting the lysosomal degradation of eEF1A1

152 views | Jun 07 2023

Anisomycin has been found to inhibit CVB type 3 infection and reduce viral replication by promoting lysosomal degradation of eEF1A1, which makes it a potential antiviral candidate for the treatment of CVB infection. [Read the Full Post]

Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer

80 views | Jun 07 2023

This study demonstrates that aberrant RNA m5C modification via the NSUN2-YBX1-QSOX1 axis plays a critical role in mediating intrinsic resistance to gefitinib in EGFR-mutant NSCLC. [Read the Full Post]